Role of pyroptosis in melanoma: Molecular mechanisms and therapeutic potentials

Decoding the molecular mechanisms of pyroptosis and its therapeutic development prospects

This review systematically summarizes the molecular regulatory mechanisms of pyroptosis, encompassing classical and non-classical inflammasome pathways, activation and modulation of gasdermin proteins, and the intricate signaling networks involved.

The gasdermin family: from pyroptosis mechanisms to therapeutic targets

The gasdermin (GSDM) family of proteins has emerged as the central executioner of pyroptosis, a form of inflammatory cell death characterized by plasma membrane rupture and the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β), IL-18 and high mobility group protein B1 (HMGB1). Emerging evidence indic...

Gasdermin-mediated pyroptosis as a prognostic biomarker and therapeutic target in hepatocellular carcinoma.

Examination of molecular circuitry linking pyroptosis with inflammasomes, metabolic stress, mitochondrial dysfunction, hypoxia, and epigenetic regulation in HCC suggests regulated pyroptosis may represent a promising immunomodulatory framework for improving precision therapy in HCC.

Innate immune sensors of inflammasomes and PANoptosomes: structural–mechanistic insights and therapeutic implications

Innate immunity provides a critical first line of defense against pathogens and homeostatic perturbations. Pattern recognition receptors detect these disruptions and initiate immune responses through multi-protein complex formation to drive inflammatory signaling and cell death pathways. Key cytosolic complexes formed...

Pyroptosis in Triple-Negative Breast Cancer: From Inflammasome Signaling to Tumor Immune Remodeling and Translational Therapeutic Strategies.

This review critically examines pyroptosis-TIME crosstalk in TNBC, prioritizing TNBC and breast cancer evidence while using non-breast cancer findings only as mechanistic comparators when they clarify conserved inflammasome or gasdermin biology.

Immunogenic cell death: synergizing ferroptosis and cuproptosis to overcome immunotherapy resistance