Author

Hany E. Marei

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Review Open access Aug 2026

Investigating the role of costimulatory domains in enhancing CAR-T cell persistence in TNBC.

This work summarizes how costimulatory domains can mediate the persistence, function, and therapeutic potential of CAR-T cells in triple-negative breast cancer (TNBC), a highly aggressive malignancy with limited treatment options and an immunosuppressive tumor microenvironment. Although CAR-T cell therapy has produced...

Hany E. Marei, G. Pozzoli, C. Cenciarelli · Cancer Gene Therapy · 0 citations

#gene editing Review Open access Sep 2026

Recent advances in molecular mechanisms to improve the efficacy of CAR-T cell therapy for viral diseases, cancer, and autoimmune diseases

This review synthesizes recent advances in molecular engineering strategies that enhance CAR-T cell function beyond conventional receptor design and discusses how receptor engineering, genome editing, transcriptional and epigenetic regulation, metabolic reprogramming, synthetic gene circuits, and safety-control platfor...

Hany E. Marei, G. Pozzoli, S. Caratelli et al. · Stem cell research & therape... · 0 citations

#gene editing Review Open access Aug 2026

Stem cell–based therapies in pediatric disorders: translational advances, unresolved challenges, and future horizons

This paper will provide the current information on stem cells used in the treatment of children and the many different types of stem cells, including: hematopoietic stem cells (and their derivatives), mesenchymal stem cells (and their derivatives), induced pluripotent stem cells, embryonic stem cells, tissue-specific p...

Hany E. Marei · Stem cell research & therape... · 0 citations