Gang Zhang

ATP1A3-related neurological disorders: updated insights into clinical heterogeneity, molecular mechanisms and precision therapeutics

This narrative review summarizes recent advances in the clinical spectrum, genotype-phenotype correlations, and multilevel pathogenic mechanisms of ATP1A3-related disorders and highlights emerging therapeutic directions, including mechanism-based targeting, antisense strategies, and genome editing approaches such as ba...

Genotype–Phenotype Correlations and Their Implications for Personalized Genetic Counseling in 103 Patients With PRRT2 Mutations

It is confirmed that PRRT2‐associated disorders are primarily driven by predicted LOF mutations and a genotype‐phenotype‐treatment response continuum model based on residual PRRT2 protein activity is established, which provides a critical framework for prognosis assessment and personalized genetic counseling.

Joint Effects of Metabolic Syndrome and Polygenic Risk Score on Lung Cancer Incidence and Mortality: A Prospective Cohort Study.