Colorectal cancer (CRC) has shown significant heterogeneity regarding its response to immunotherapy. Long-lasting, beneficial effects have been observed in mismatch repair-deficient, microsatellite instability-high (dMMR/MSI-H) tumours, while mismatch repair-proficient, microsatellite stable (pMMR/MSS) tumours have rem...
D. Bartusik-Aebisher, Daniel Roshan Justin Raj, Izabella Wilk et al.· Molecules· 0 citations
Glioblastoma multiforme (GBM) remains one of the most difficult malignant brain tumours to treat due to its infiltrative nature, cellular heterogeneity, resistance to treatment and limited drug penetration across the blood–brain barrier. The combination of photodynamic therapy (PDT) with chemotherapy within a single na...
P. Woźnicki, D. Aebisher· International Journal of Mol...· 0 citations
Protoporphyrin IX (PpIX) occupies a unique nexus in photodynamic therapy (PDT) by bridging the endogenous metabolism of heme biosynthesis with highly efficient, light-induced cytotoxicity. Administered via its precursor 5-aminolevulinic acid (5-ALA) or its derivatives, intracellularly generated PpIX undergoes intersyst...
R. Marunych, D. Bartusik-Aebisher, Klaudia Dynarowicz et al.· Micro· 0 citations
Porphyrins and their derivatives represent one of the most adaptable classes of compounds in contemporary biomedical research, bridging the crucial gap between diagnostic imaging and therapeutic intervention. This comprehensive review examines the evolution of porphyrin-based compounds and their therapeutic application...
Urszula Rodzoń-Wańczura, D. Aebisher, Tamil Selvan Ramesh et al.· Molecules· 0 citations
Breast cancer imaging is central to screening, diagnosis, staging, treatment monitoring, and post-treatment surveillance, but image interpretation remains limited by variable image quality, interobserver variability, false-positive findings and heterogeneous tumor biology. This narrative review summarizes current appli...
D. Bartusik-Aebisher, Sara Czech, Jakub Szpara et al.· Applied Sciences· 0 citations
Although photodynamic therapy (PDT) is a recognised treatment for the premalignant keratinocytic lesion actinic keratosis (AK) and selected superficial skin cancers, poor photosensitiser delivery, restricted light penetration and tumour hypoxia can significantly restrict its effectiveness. Recent advances in nanomedici...
D. Bartusik-Aebisher, Izabella Wilk, D. Aebisher· International Journal of Mol...· 0 citations
Photodynamic therapy (PDT) is a minimally invasive therapeutic approach based on the light-induced activation of a photosensitizer in the presence of molecular oxygen, resulting in the generation of reactive oxygen species, including singlet oxygen. Despite local selectivity and low systemic toxicity, reproducibility o...
R. Marunych, D. Bartusik-Aebisher, Klaudia Dynarowicz et al.· International Journal of Mol...· 0 citations
The effectiveness of chemotherapy in colorectal cancer (CRC) is significantly reduced by acquired chemoresistance to 5-fluorouracil (5-FU), oxaliplatin and irinotecan. This structured narrative review synthesises mechanistic, preclinical, translational and clinical evidence underlying resistance to these agents. Distin...
D. Bartusik-Aebisher, Izabella Wilk, B. George et al.· Cells· 0 citations
Despite decades of clinical validation, glioblastoma (GBM) treatment remains tethered to a dismal 15-to-16-month survival plateau, heavily thwarted by the ys blood–brain barrier (BBB) and profound cellular heterogeneity. While the 2021 World Health Organization Classification of Tumors of the Central Nervous System (WH...
D. Aebisher, Jakub Tylutki, Angelika Myśliwiec et al.· Genes· 0 citations
Overall, PDT combination design should be guided by whether adjunctive agents support or undermine photosensitizer accumulation, oxygen availability, ROS-mediated cytotoxicity, and immune activation, when selected according to mechanistic compatibility.
Ilaf Naser, D. Bartusik-Aebisher, Barbara Smolak et al.· Biomedicines· 1 citation
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
