Aug 2026· Physics in Medicine and Biology· 0 citations
Medicine
Abstract
Accurate delineation of the gross tumor volume (GTV) is critical for determining the efficacy of radiotherapy in esophageal cancer. Conventional segmentation methods either rely solely on end-to-end learning from imaging features, which often struggle to address small tumor volumes and ambiguous boundaries, or incorporate coarse masks as spatial priors but fail to integrate the pathological semantics essential for clinical decision-making. This disconnect can lead to segmentation results that are poorly aligned with clinical practice. To address these limitations, this study proposed the Mask Guidance and Text Prompting Segmentation (MGTP-Seg) framework. Based on UNETR, MGTP-Seg innovatively integrates a mask guidance branch and a text prompting branch. The mask guidance branch utilizes pre-segmented masks from nnU-Net to provide spatial priors, while the text prompting branch dynamically integrates clinically relevant semantics from large language models into the visual feature space via learnable prompt tuning. Through adaptive fusion and bidirectional alignment, these branches enable synergistic integration of imaging details, spatial priors, and high-level clinical knowledge in an end-to-end manner. Experiments on multi-center datasets confirm that MGTP-Seg delivers accurate and robust segmentation on both internal and external validation sets. This work demonstrates that MGTP-Seg not only provides an accurate, interpretable, and clinically relevant solution for automatic GTV delineation, but also offers a novel methodological framework to fuse spatial priors with semantic knowledge in medical image analysis.
FLARE is proposed, a novel framework that endows VLAs with robust error recovery capabilities through a ``Retry" and ``Reset" Paradigm, and significantly improves task success and robustness.
Ganlong Zhao, Zijia Tang, Xingping Chen et al.· 3 citations
LifeSciBench is introduced, a benchmark of 750 expert-authored tasks designed to evaluate whether language models can handle realistic life science research work, with each constituent task paired with a human expert-written rubric.
Amelia Liu, Andrew Ho, Anne Marie Droste et al.· bioRxiv· 2 citations
Experimental results show that CritICL consistently outperforms standard in-context learning and achieves performance competitive with or superior to test-time scaling methods, while requiring significantly fewer generations and lower token cost.
Yu-Fan Wu, Yinghui He, Zhengyi Hu et al.· 1 citation
TestifAI, a deep learning testing framework for efficient and accurate estimation of robustness against combinations of perturbations, is proposed and partial model tomography is introduced, a novel approach to reconstructing model behaviour in a multi-perturbation space from tests that apply only a small number of perturbations.
Arooj Arif, T. Hartung, E. Botoeva et al.· 1 citation
The complex multi-energy coupling characteristics inherent to integrated energy system (IES) present unprecedented challenges for the implementation of low-carbon scheduling. Existing optimization methods often exhibit limitations in system scalability, algorithm adaptivity, and carbon reduction efficacy for complex IES. This paper proposes a Large Language Model (LLM)-Embedded Multi-Agent Reinforcement Learning (LEMARL) to address the aforementioned issues. The proposed method integrates the global perception capability of LLMs with the dynamic optimization capability of MARL. Specifically, the LLM-Embedded module generates high-quality reward functions and policy frameworks from a global perspective, while the MARL module leverages these LLM-generated strategies for distributed interactive iterations—greatly enhancing computation efficiency and scalability. Simulation results demonstrate that LEMARL reduces carbon emissions by 7.76% and simultaneously decreases operating costs by 4.49% in a small-scale IES. Furthermore, LEMARL also exhibits superior applicability and scalability in large-scale IES of the IEEE 141-bus power grid integrated with 51-node thermal system.
Chen Xia, Tong Gou, Yinliang Xu et al.· IEEE Transactions on Smart G...· 1 citation
General-purpose language models can reason and synthesize knowledge, but complex work also requires sustained interaction with files, information sources, and executable code, together with state maintenance, failure recovery, and verifiable delivery. We call this \emph{working capability}: sustained, verifiable progress toward a real-world objective. Apodex 1.1 develops this capability along two complementary dimensions. \emph{Environment Scaling} expands the diversity and verifiability of executable file, search, and code environments, while \emph{Agentic Coordination Scaling} trains agents to decompose long-horizon tasks, delegate parallel work, integrate asynchronous results, and replan. A shared execution harness and AgentOS maintain task state and provenance across tools and agents, and training turns environment trajectories and coordination traces into reliable behavior. Across complex professional work, finance, scientific research, mathematics, coding, and search, Apodex 1.1 reaches the leading performance band despite using a substantially smaller model than many frontier systems. The 35B-parameter Apodex 1.1 Mini further retains strong working capability in a locally deployable form. These results ground agentic intelligence in useful, verifiable work completed over time and advance our goal of building a \emph{Heavy-Duty Solver} for ambitious, long-running tasks.
Apodex Team B. An, B. Li, B. Wang et al.· 1 citation
A new method for surgically removing training examples from a model reveals that as datasets grow, the link between what a model learns and what it produces dissolves.
