Ameliorative Role of fenugreek Oil Against Lead Acetate Trihydrate-Induced Hepatic, Renal and Testicular Injury in Wistar Albino Rats: Insights into Bcl-2 Expression and sodium/potassium balance.
Sep 2026· Biological Trace Element Research· 0 citations· 36 references
Medicine
TL;DR
Concurrent administration of fenugreek seed oil may attenuate PbAc-induced hepatic, renal and testicular histopathological damage in rats, and this protectivity effect was associated with the restoration of sodium/potassium balance, and upregulation of Bcl-2 expression.
Background:
Lead (Pb) is a heavy metal that impairs organ function and immune competence in teleost fish.
Aim:
This study explored the protective effect of dietary milk thistle extract (Silybum marianum; MT) as a natural feed additive against sub-lethal lead acetate-induced toxicity in common carp (Cyprinus carpio...
Safaa H. Aboolo, Hebatallah Saad, R. Diabb et al.· Open Veterinary Journal· 0 citations
INTRODUCTION
Lead poisoning poses a significant global health challenge, impairing immune function and inducing oxidative stress and inflammation, particularly in the spleen. Ferula assa-foetida, a traditional medicinal plant, exhibits antioxidant and anti-inflammatory properties, but its protective effects against lea...
A. Dehghan, Seyyed Majid Bagheri, M. Esmailidehaj et al.· Cardiovascular & Hematologic...· 0 citations
Ginkgo biloba and fenugreek extracts exhibited significant hepatoprotective and antioxidant effects against CCl₄-induced liver injury and may represent a promising natural therapeutic strategy for preventing hepatic damage.
Bayadir Ali Wannas Khodair, Rusul Mazin Mohammed Burair, N. A. Al-Murshedy et al.· Uttar Pradesh Journal of Zoo...· 0 citations
Cadmium is a dangerous environmental contaminant that injures multiple organs, including the liver. Curcumin is a powerful anti-tumoral, anti-inflammatory, anti-carcinogenic, and hepatoprotective substance. The purpose of this study was to analyze the influence of Cadmium Chloride on rat livers (histopathological, immu...
N. T. Sabra, Fatima El Zahra Sabry, Manar Ahmad et al.· European Journal of Anatomy· 0 citations
Ginger is supported as a promising natural agent for mitigating heavy metal nephrotoxicity through antioxidant, anti-inflammatory, anti-apoptotic, and metal-chelating mechanisms.
E.O. Onigbo, U. Ukoha, C. Esomchi et al.· Journal of Molecular Histolo...· 0 citations
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