TL;DR
Childhood drug-resistant epilepsy was the strongest predictor of persistent adult seizures and disability and TSC2 mutations were linked to a more severe phenotype but does not predict the course of epilepsy in adulthood, supporting early, optimized seizure management.
It is suggested that repeat sEEGs may help guide effective treatment in children with multifocal epilepsy, while multifocal networks may necessitate additional sEEG evaluations and subsequent surgeries, favorable seizure outcomes can be achieved.
Young age at diagnosis of focal epilepsy, diagnosis of cortical dysplasia, MTS, and presence of complex partial seizures are risk factors for drug-resistant epilepsy.
Real-world insights into RSE in a resource-limited setting are offered, highlighting preventable causes, management complexity, and high care demands, and favorable outcomes are often achievable.
Early-onset epilepsy in infancy exhibits heterogeneous features and the ILAE framework facilitates a systematic diagnostic approach and supports clinical management in pediatric patients.
Generalized seizures with tonic clonic presentation were most common seizure type reported and were classified according to International League Against Epilepsy classification 1989.
Most CYE have a wide spectrum of medical, neurological, psychiatric, and neurodevelopmental comorbidities, which need to extend beyond seizures, and their evaluation and management need to extend beyond seizures.
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