2026· Advances in Immunology· Vol 171, pp.
437-462
· 0 citations
Medicine
TL;DR
This chapter focuses on the diversification of neurodegenerative CNS microglial states, the interaction of microglia with neurons, glial cells, adaptive immune cells, and the vasculature, and how this framework provides a basis for therapeutic strategies aimed at modulating, replacing, or reprogramming microglia in neurodegenerative disease.
It was found that AD was characterized by altered microglial composition and rewiring of intercellular communication, including disease-specific signaling pathways and distinct interaction hubs.
Loren dos Santos, R. Vialle, Natacha Comandante-Lou et al.· bioRxiv· 0 citations
This review summarizes recent advances in microglial biology across acute brain injury, neurodegenerative and demyelinating disorders, central nervous system infections, and psychiatric and neurodevelopmental diseases and provides new opportunities for precision therapy.
Jie Chen, Wangzheqi Zhang, Li-Zhou Song et al.· Clinical and Translational M...· 0 citations
This chapter provides a comprehensive synthesis of microglial biology across multiple interfaces, including transcriptomic, lipid-associated metabolic, cell senescence, and metabolic reprogramming, and positions microglia biology as a metabolically plastic, spatially organized immune-regulated microenvironment that can...
Vaishali Saini, Srija Mukherjee, Chaitali Vora et al.· Advances in Immunology· 0 citations
The molecular mechanisms underlying astrocyte–microglia molecular crosstalk in physiological and pathological contexts are summarized, with particular emphasis on the secreted mediators that dynamically reprogram glial signaling networks.
P. Argente-Arizón, Belén Monge-Ochoa· Frontiers in Molecular Neuro...· 0 citations
This review synthesizes current knowledge and provides updated insights into the mechanisms by which astrocytes and microglia communicate during embryonic development of the CNS, participate in network physiology in the adult CNS, and engage in cellular responses to disease, highlighting how their interactions contribu...
Alberto Javier Ramos, A. Villarreal· Frontiers in Network Physiol...· 0 citations
A microglial immunometabolic trajectory framework is proposed in which metabolic states are viewed as branching and potentially reversible determinants of cellular function rather than fixed stages of a universal disease pathway.
Qiao-Qiao Cui, Ke Zheng, Qi-Yun Liu et al.· Frontiers in Molecular Neuro...· 0 citations
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