Plastic pollution is an emerging yet understudied environmental risk to the immune system. Once ingested, microplastic and nanoplastic particles (MNPs) can translocate from the gut to internal organs1-3, with macrophages serving as primary targets4. Kupffer cells (KCs), the liver-resident macrophages, have a central ro...
Nikola Makdissi, Maria Francesca Viola, L. Steinheuer et al.· Nature Metabolism· 0 citations
DAXX, a histone chaperone and RTE repressor, is downregulated during aging, preserves microglia homeostasis and inhibits cellular senescence, highlighting the importance of heterochromatin maintenance in preserving adult microglial identity and plasticity, with broader implications for brain homeostasis, healthy aging...
Xin Yan, Christina Georgopoulou, Hang-Mao Lee et al.· Nature Neuroscience· 1 citation
This chapter focuses on the diversification of neurodegenerative CNS microglial states, the interaction of microglia with neurons, glial cells, adaptive immune cells, and the vasculature, and how this framework provides a basis for therapeutic strategies aimed at modulating, replacing, or reprogramming microglia in neu...
Hao Huang, E. Mass· Advances in Immunology· 0 citations
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