Spatial distribution and prognostic significance of hemorrhagic imaging features in brain metastases from metastatic renal cell carcinoma

Timing and prognosis of brain metastasis development in breast cancer by subtype.

Limited data on the timing of brain metastases development and subsequent prognosis by breast cancer subtype exist. We retrospectively evaluated a cohort of 671 patients diagnosed with brain metastases secondary to breast cancer. Patients were categorized by subtype: human epidermal growth factor receptor 2-positive (H...

94 Outcome of patients with metastatic lung cancer presenting with synchronous brain metastases – A single centre; 5 year retrospective analysis

There was so significant difference in number of patients receiving local brain treatment based on PDL1 and molecular genetic status that Prospective randomised clinical trials are needed to test the utility of upfront local intracranial treatments in this cohort.

Risk stratification for unfavorable outcome after resection of selected brain metastases in patients with multiple brain metastases

Brain metastases in lung cancer patients: Correlation between radiologic phenotypes and outcome parameters in neurosurgically treated cohort

Background Up to 50% of Brain metastases (BM) are associated with lung cancer. Different radiologic features such as tumor size, anatomical location and peritumoral edema affect the clinical course. However, their impact on prognosis and survival is controversial. Patients and Methods A retrospective study of lung canc...

Characterizing intradural spinal metastasis in the metastatic cascade: clinical course, dissemination timing, and molecular features in 69 patients

37 Deciphering the Genomic Landscape of Renal Cell Carcinoma Brain Metastases

Abstract Background Brain metastases from renal cell carcinoma (RCC) remain a major cause of morbidity and mortality, yet the genomic features associated with metastatic dissemination remain poorly understood. Methods Whole-exome sequencing was performed on 72 RCC brain metastasis samples with matched normal. To identi...