How to Build a Quantum Supercomputer: Scaling from Hundreds to Millions of Qubits
Masoud MohseniArtur SchererK. Grace JohnsonOded WertheimMatthew OttenNamit AnandNavid Anjum AaditYuri AlexeevGilad Ben-ShachKirk M. BresnikerKerem Y. CamsariBarbara ChapmanSoumitra ChatterjeeShuvro ChowdhuryGebremedhin A. DagnewTom DvirAniello EspositoFarah FahimMichael FergusonMarco FiorentinoArchit GajjarKaterina GratseaGaurav GyawaliChristian HeiterAli H. Z. KavakiAbdullah KhalidXiangzhou KongBohdan KulchytskyyElica KyosevaRuoyu LiP. Aaron LottIgor L. MarkovRobert F. McDermottLucas MoraisGiacomo PedrettiPooja RaoEleanor RieffelAllyson SilvaJohn SoreboPanagiotis SpentzourisZiv SteinerBoyan TorosovDavide VenturelliRobert J. VisserZak WebbXin ZhanYonatan CohenPooya RonaghAlan HoRaymond G. BeausoleilJohn M. Martinis
Sep 2026
Artificial IntelligenceQuantum Computing
Abstract
In the span of four decades, quantum computation has evolved from an intellectual curiosity to a potentially realizable technology. Today, small-scale demonstrations have become possible for quantum algorithmic primitives on hundreds of physical qubits. Nevertheless, there are significant outstanding challenges in quantum hardware, fabrication, software architecture, and algorithms on the path towards a full-stack scalable quantum computing technology. Here, we provide a comprehensive review of these scaling challenges. We show how to facilitate scaling by adopting existing semiconductor technology to build much higher-quality qubits, employing systems engineering approaches, and performing distributed heterogeneous quantum-classical computing. We provide a detailed resource and sensitivity analysis for quantum applications on surface-code error-corrected quantum computers given current, target, and desired hardware specifications based on superconducting qubits, accounting for a realistic distribution of errors. We provide comprehensive resource estimates for several utility-scale applications including quantum chemistry calculations, catalyst design, NMR spectroscopy, and Fermi-Hubbard simulation. We show that orders of magnitude enhancement in performance could be obtained by a combination of hardware improvements and tight quantum-HPC integration. Furthermore, we introduce high-performance architectures for quantum-probabilistic computing with custom-designed accelerators to tackle today's industry-scale classical optimization, machine learning, and quantum simulation tasks in a cost-effective manner.
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