TL;DR
High MCT4 expression in TAMs may be associated with metabolic reprogramming toward glycolysis, and could promote M2 polarization of TAMs, thereby contributing to HCC progression and poor clinical outcomes.
A novel mechanism by which FOXP1 transcriptionally upregulates NUSAP1 expression results in glycolytic metabolic reprogramming that induces TAM M2 polarization and promotes HCC progression, identifying a potential therapeutic avenue for reversing the immunosuppressive microenvironment in HCC.
The PDX model exhibits a unique stemness regulatory pattern closer to clinical practice, providing new molecular targets and experimental basis for the metabolic targeted therapy of esophageal cancer.
Hypoxia drives TAM heterogeneity in HCC via an H‑TAM‑intrinsic HIF‑1α-uPA axis that engages uPAR on HCC cells to promote metastasis, and dasatinib is a promising therapy to block this axis and improve outcomes.
It is proposed SLC25A1 is associated with metabolic reprogramming in HCC and contribute to tumor progression by promoting lipogenesis and offering a promising therapeutic target for early intervention and treatment.
The mechanistic role of sorbitol metabolism in driving HCC progression through shaping an immunosuppressive microenvironment is uncovered and the sorbitol metabolism scoring system may serve as a novel prognostic biomarker and provides a theoretical foundation for precision treatment strategies, such as Irofulven-targe...
Hepatocellular carcinoma (HCC) poses a significant global health burden with limited therapeutic options, particularly for non-viral etiologies. The mitochondrial solute carrier SLC25A43 is implicated in cellular redox homeostasis, yet its role in HCC remains unclear. This study aimed to comprehensively investigate the...
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