TL;DR
ADH6 and BDH1 were identified as significantly downregulated genes associated with patient survival in CRC and demonstrated promising tissue-based diagnostic discrimination between tumor and normal samples.
Collectively, m6A-related genes are dysregulated in breast cancer and correlate with patient outcomes, highlighting their biomarker potential, with YTHDF3 warranting in-depth investigation.
Although specific mRNAs serve as key structural hubs, hsa-miR-378c and hsa-miR-449a emerge as robust independent prognostic biomarkers, providing important insights into TNBC risk stratification and potential targeted therapeutic strategies.
The results suggest that HSD17B2 is frequently downregulated in precancerous lesions and early-stage CRC, which may contribute to elevated estradiol levels and a tumor-promoting microenvironment, and HSD17B11 and HSD17B11 warrant further investigation as candidate biomarkers for distinguishing CRC from benign and preca...
This study integrates multi-omics datasets to identify candidate biomarkers that may influence TNBC progression and modulate therapeutic response and nominate CCND2 and KIF1A as candidate biomarkers and potential therapeutic targets in TNBC.
The proposed glutathione metabolism-related signature demonstrated prognostic value in both training and validation cohorts and was associated with immune characteristics, pathway enrichment patterns, genomic alterations, and tumor mutation burden in LUAD.
Hepatocellular carcinoma (HCC) poses a significant global health burden with limited therapeutic options, particularly for non-viral etiologies. The mitochondrial solute carrier SLC25A43 is implicated in cellular redox homeostasis, yet its role in HCC remains unclear. This study aimed to comprehensively investigate the...
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
