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Author

M. Peymani

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2026

Allele-specific disruption of KRAS p.G12V in colorectal cancer cells using electroporated Cas9 RNPs

Objective(s): Colorectal cancer (CRC) is a major cause of mortality, and KRAS mutations drive tumorigenesis and therapy resistance. Although CRISPR-Cas9 enables precise genome editing, intracellular delivery of Cas9 ribonucleoproteins (RNPs) remains challenging. We evaluated direct electroporation of Cas9-sgRNA RNPs ta...

Firouzeh Morshedzadeh, Samaneh Sharif, M. Peymani et al. · 0 citations
Open access Jul 2026

Identification of RNA binding proteins targeting TP53, RB1 and PTEN in colorectal cancer as potential biomarkers for diagnosis, drug resistance, sensitivity and prognosis

Twenty-two RBPs were identified as candidate binding-associated regulators of key tumor suppressors and seven RBPs involved in prominent pathways were identified as candidate prognostic biomarkers requiring further validation in independent cohorts before any clinical application can be considered in CRC, although thes...

A. Asadi, Mehrdad Hashemi, M. Peymani et al. · 0 citations
Aug 2026

Unveiling Prognostic Biomarker in Colorectal Cancer: ADH6 and BDH1 through Oxidoreductase Gene Family Dysregulation

ADH6 and BDH1 were identified as significantly downregulated genes associated with patient survival in CRC and demonstrated promising tissue-based diagnostic discrimination between tumor and normal samples.

F. Kaviani, Samaneh Dalali, Mohammad Mahdevar et al. · 0 citations

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