These findings provide the first comprehensive molecular characterization of EVs released by MCPyV-positive MCC cells and establish a foundation for investigating the contribution of EV-mediated communication to MCC biology and tumor–microenvironment interactions.
Aim: Extracellular vesicles (EVs) are emerging as important mediators in myeloproliferative neoplasms (MPNs), but the characteristics of distinct EV subtypes remain unclear. This study aimed to characterize the molecular heterogeneity of MEG-01-derived large EVs (lEVs) and small EVs (sEVs).
Methods: lEVs and sEVs were...
Xiao-Gang Zhang, S. Sehra, Cynthia Timmers et al.· Extracellular Vesicles and C...· 0 citations
Extracellular vesicles (EVs) are a heterogeneous population of membrane-bound particles that mediate intercellular communication through the horizontal transfer of biologically active cargo, including microRNAs (miRNAs). Although numerous miRNAs have been identified in EVs, it remains unclear which miRNAs are selective...
Marzena Lenart, Izabela Siemińska, A. Mordel et al.· Tissue & Cell· 0 citations
Background Extracellular vesicles (EVs) have been investigated as promising vehicles for delivering drugs and microRNAs (miRNAs) in distinct types of cancer. However, their use as a delivery system in papillary thyroid carcinoma (PTC) remains underexplored. PTC is the most prevalent subtype of thyroid cancer, and despi...
Mônica Pezenatto Dos Santos, Nathalia Leal Dovaizem, Isabelle Nogueira Silva et al.· Frontiers in Endocrinology· 0 citations
The findings suggest that plasma sEVs contribute to systemic immune modulation in HNC by inducing dysfunctional T-cell phenotypes and underscores the need for further investigation into their relevance for immunotherapeutic strategies in HNC.
Luisa Tengler, Edwin K. Jackson, K. Bieback et al.· British Journal of Cancer· 0 citations
Cytokines are signaling molecules produced by various cell types, including immune cells, and play important roles in tumor development and progression. Extracellular vesicles (EVs) are small membrane-bound particles secreted by all cell types, including cancer cells. EVs mediate intercellular communication throu...
Hang Minh Huynh, M. Nawaz, S. Jabeen et al.· BMC Cancer· 0 citations
Treatment with cancer cell-derived sEVs may be associated with impaired in vitro differentiation of C2C12 myoblasts, and enrichment of terms related to mRNA metabolism, the cell cycle, and the proteasome is revealed.
Woo-Jin Lee, S. Yang, H. Yu et al.· International Journal of Mol...· 0 citations
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