Author

Patrick Blümke

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#protein folding Open access Oct 2026

Genes controlling polysaccharide synthesis, protein folding and basic metabolism ensure intra-host cell adaptation and replication of Yersinia enterocolitica

Pathogenesis of yersiniosis comprises cell-invasive events in which the bacteria subvert the endocytic-autophagolysosomal pathway of infected host cells to create an intracellular niche for bacterial replication. To determine potential virulence factors that enable intracellular proliferation of Yersinia enterocolitica...

J. Brinkmann, Jia-Bin Huang, Patrick Blümke et al. · bioRxiv · 0 citations

Open access Sep 2026

Variant-specific nucleocapsid mutations shape host innate immune trajectories during SARS- CoV-2 infection

It is found that the mutations induce distinct transcriptional and translational alterations: rN-Alpha drives a stealth-like infection characterized by sustained translation efficiency and specific evasion of the 2’-5’-oligoadenylate synthetase (OAS) innate immune sensor, whereas rN-Delta and rN-BA trigger a highly ele...

J. Berger, Jonas Schröder, Timothy K. Soh et al. · bioRxiv · 0 citations

Aug 2026

Multi-omics characterization of extracellular vesicles derived from virus-positive Merkel cell carcinoma cells

These findings provide the first comprehensive molecular characterization of EVs released by MCPyV-positive MCC cells and establish a foundation for investigating the contribution of EV-mediated communication to MCC biology and tumor–microenvironment interactions.

U. Westerkamp, Patrick Blümke, Amanda Salviano-Silva et al. · bioRxiv · 0 citations