Open access
Using Manganese‐Enhanced DCE‐MRI to Assess Blood‐Cerebrospinal Fluid Barrier Transport
C. Perera
Zhiping Feng
S. Nizari
Phillip Muza
C. Katsiva
T. Kalber
M. Lythgoe
I. Harrison
Daniel J. Stuckey
Jack A. Wells
Medicine
Abstract
We developed a dynamic, heavily T2‐weighted (hT2w) FLAIR protocol to resolve acute Mn2+ transport kinetics, as a proxy for Ca2+, across the choroid plexus (ChP)—cerebrospinal fluid (CSF) interface, in vivo. By quantifying intercompartmental Mn2+ dynamics, and comparing these with Gd‐DOTA, we sought to characterize blood‐CSF‐barrier (BCSFB)‐mediated tracer transport, combining high in‐plane resolution and 4‐min temporal sampling.