Daniel J. Stuckey

Using Manganese‐Enhanced DCE‐MRI to Assess Blood‐Cerebrospinal Fluid Barrier Transport

We developed a dynamic, heavily T2‐weighted (hT2w) FLAIR protocol to resolve acute Mn2+ transport kinetics, as a proxy for Ca2+, across the choroid plexus (ChP)—cerebrospinal fluid (CSF) interface, in vivo. By quantifying intercompartmental Mn2+ dynamics, and comparing these with Gd‐DOTA, we sought to characterize blood‐CSF‐barrier (BCSFB)‐mediated tracer transport, combining high in‐plane resolution and 4‐min temporal sampling.