Identification and computational analysis of B-cell epitopes on the hemagglutinin protein of the H3N2 influenza virus

Molecular Design of Novel mRNA and Multiepitope Subunit Vaccines for H10N5 Avian Influenza A virus

A multi-epitope-based DNA vaccine confers cross-protection against influenza A H1N1 and H3N2 viruses

Background and Objectives: Influenza A virus remains a major global health concern because antigenic drift reduces the long-term efficacy of current vaccines. This study evaluated a multi-epitope DNA vaccine targeting conserved regions of hemagglutinin (HA) and polymerase acidic (PA) proteins from influenza A/H1N1 and...

Identification of a novel conserved B-cell epitope in the glycoprotein of rabies virus

This study identifies a novel, highly conserved with conservative substitutions linear B-cell epitope on the RABV glycoprotein, providing a precise molecular target for the rational design of next-generation epitope-based vaccines and specific diagnostic tools.

Identification of a novel linear B-cell epitope in the N-terminus of varicella-zoster virus glycoprotein B

A novel linear B-cell epitope, 97LGDGDEIR104, is identified within the flexible N-terminal region of gB, which was critical for antibody binding, revealing a new antigenic site on VZV gB.

Novel linear B-cell epitopes mapping with monoclonal antibodies to VP3 protein from bluetongue virus serotype 1.

Bluetongue is an infectious disease affecting domestic and wild ruminants that is caused by bluetongue virus (BTV). VP3 is the major component of the BTV inner capsid and a structural protein that is essential for viral maturation. The B-cell epitopes on BTV-1 VP3 that are recognized by the humoral immune response rema...

Monoclonal antibody 1B9 against the African swine fever virus viroporin pB169L: molecular characterization and epitope mapping

Introduction The African swine fever virus (ASFV) viroporin pB169L is a conserved membrane protein, but well-defined reagents for its detection and molecular characterization remain limited. Methods A soluble recombinant antigen comprising the non-transmembrane regions of pB169L was used to generate a mouse monoclonal...