TL;DR
The integration of QSRR, ML, and DoE offers a viable foundation for developing RP-HPLC methods for antiviral drug analysis that are predictive, effective, and environmentally friendly.
Traditional HPLC method development relies on trial-and-error, one-factor-at-a-time approaches that struggle to capture complex, multivariate interactions among method parameters, often resulting in suboptimal separations and transfer failures. While Design of Experiments and Analytical Quality by Design frameworks add...
The increasing complexity of pharmaceutical, biotechnological, and environmental matrices is shifting analytical method development from empirical trial-and-error approaches toward structured, predictive, and data-driven strategies. These strategies emphasize robustness, reproducibility, and regulatory compliance a...
Objective: This study focused on designing and validating a reliable and efficient Quality by Design assisted RP-HPLC analytical procedure for efavirenz in bulk and tablet dosage form. Methods: The significant analytical variables (CMPs) were optimized by using Central Composite Design, analytical variables; including...
Abstract Reliable and stability-indicating analytical methods are required to support the development and quality control of Medroxyprogesterone Acetate (MPA), particularly in emerging solid-state pharmaceutical systems such as microcrystals. In this analytical method development and validation study, a stability-indic...
For the quantitative determination of Tafamidis in bulk and pharmaceutical dosage forms, a straightforward, accurate, precise, and environmentally friendly reverse-phase high-performance liquid chromatographic (RP-HPLC) method was developed and validated. To achieve optimal chromatographic performance, several stationa...
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