TL;DR
This chapter provides an overview of numerous computational approaches developed to reconstruct circRNA-miRNA-mRNA networks, ranging from specific circRNA-oriented applications to sequencing-based tools, each with distinct strengths and limitations.
How circRNAs regulate homeostasis in normal tissues, how dysregulated expression of circRNAs impacts various cancers and emerging therapeutic technologies that build upon their unique features are reviewed.
The circRNA-SIRT1 network is proposed as a context-dependent post-transcriptional regulatory network linking non-coding RNA (ncRNA) biology to immunometabolic and stress-response pathways and emphasized as a promising platform for precision diagnostics and disease-specific therapeutic interventions.
This chapter explores the biomedical significance of ceRNAs, highlighting their role in modulating gene expression and their potential implications in disease, and summarizes available tools, resources, and practical examples for studying lncRNA-miRNA interactions to aid researchers in navigating this sophisticated reg...
This review explores the current understanding of intrinsic molecular features dictating circRNA stability and provides an integrated perspective for understanding circRNA-centered regulation of RNA stability.
This review follows the evolution of piRNA research, highlighting advances in their biogenesis, molecular mechanisms, and multifaceted roles in gene regulation and outlines how recent computational developments have improved functional and disease-association prediction.
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