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L. Cascione

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#protein folding Open access Oct 2026

BTK/BCL2 dual targeting enhances apoptosis in marginal zone lymphoma: preclinical activity of tacabrutideg (BGB-16673) and sonrotoclax.

Tacabrutideg demonstrates potent preclinical activity in MZL as a single agent and in combination regimens, and together with the superior activity of sonrotoclax, these findings provide a strong rationale for the clinical evaluation of dual BTK degradation and BCL2 inhibition in patients with MZL.

A. Arribas, Alex Zadro, E. Civanelli et al. · Haematologica · 0 citations

2026

Integration of Omics Data to Identify Cancer-Related MicroRNA.

This chapter includes step-by-step protocols, example R code, and recommendations for integrating additional data layers such as copy number variation and DNA methylation, with the goal of improving the robustness and interpretability of miRNA-based analyses in cancer.

L. Cascione · Methods in molecular biology · 0 citations

Review 2026

Construction and Analysis of circRNA-miRNA-mRNA Regulatory Networks.

This chapter provides an overview of numerous computational approaches developed to reconstruct circRNA-miRNA-mRNA networks, ranging from specific circRNA-oriented applications to sequencing-based tools, each with distinct strengths and limitations.

S. Avesani, L. Cascione, R. Giugno · Methods in molecular biology · 0 citations