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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

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Open access Sep 2026

The atypical cadherin CELSR2 regulates distinct epithelial–mesenchymal states and oxidative phosphorylation in triple-negative breast cancer

These findings identify CELSR2 as a previously unknown regulator of epithelial-mesenchymal plasticity and reveal that heterogeneous CELSR2 expression shapes spatially and functionally distinct tumor cell populations, thereby contributing to intratumoral heterogeneity in TNBC.

Julia Koren, Nour-Islem Yanis Saidani, Abdessamad Elkaoutari et al. · 0 citations
Open access Oct 2026

DYRK1B overexpression promotes senescence-like transcriptional and secretory programs in A549 lung cancer cells.

The dual-specificity tyrosine-regulated kinase DYRK1B is frequently expressed at elevated levels in solid tumors and has been implicated in cancer cell survival, therapy resistance, and cell cycle arrest. While DYRK1B is best known for maintaining quiescence, its broader impact on cancer cell phenotypic plasticity rema...

G. Wilms, Aaron Babendreyer, Justyna Wozniak et al. · 0 citations
Open access Sep 2026

Thioredoxin reductase-1 facilitates cellular plasticity and stemness mediated by TGF-β1 in non-small cell lung cancer

This study identifies TXNRD1 as a crucial regulator of cellular plasticity and metastasis in NSCLC via the TGF-β1 pathway, suggesting that targeting TXNRD1 may reduce metastatic potential and improve patient survival.

Yaw-Dong Lang, Shin-Yuan Gu, Jou-Ho Shih et al. · 0 citations
Open access Sep 2026

NONO modulates tumorigenesis and metastatic potential of lung squamous cell carcinoma

Lung squamous cell carcinoma (LUSC) is associated with limited therapeutic options and poor clinical prognosis. The Octamer nucleotide--binding transcription factor (NONO), which lacks the POU domain, is implicated in nearly every aspect of gene regulation. It participates in various biological processes including cell...

Jin-Long Huang, Li-Ping Zhu, Wei-Qing Zhang et al. · 0 citations
Open access Aug 2026

NAT10 promotes proliferation, invasion, and epithelial–mesenchymal transition in hepatocellular carcinoma through α-tubulin acetylation

ABSTRACT Hepatocellular carcinoma (HCC) remains a global health challenge due to its high metastatic potential and poor prognosis. This study investigated the role and underlying molecular mechanisms of N-acetyltransferase 10 (NAT10)-mediated α-tubulin acetylation in HCC progression. Using Huh-7 and SNU-449 cell lines,...

Hao-gang Yu, Kan-Kai Zhu, Guo-Liang Zhang et al. · 0 citations
Open access Sep 2026

An FEV-Associated Metastasis-Initiating-Like State Linked to Tumor Cell Plasticity and Immune Niche Remodeling in Prostate Cancer

Prostate cancer progression is accompanied by dynamic remodeling of malignant cell states, whose metastatic potential and regulatory programs remain poorly defined. Here, we integrated single-cell, spatial, bulk transcriptomic, epigenomic, and experimental data to characterize malignant cell state transitions and ident...

Si-Jia Wu, Jiang-Peng Wei, Xiao-Rui Shi et al. · 0 citations

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