This review examines the biological rationale, experimental evidence, and potential clinical applicability of radiosurgical ablation of the choroid plexus for iNPH to determine the feasibility and efficacy of SRS as a potential non-invasive therapeutic option for iNPH.
BACKGROUND AND OBJECTIVES
Normal pressure hydrocephalus (NPH) affects approximately 0.2% to 2.9% of adults older than 65 years and is characterized by progressive gait impairment, cognitive decline, and urinary incontinence. Cerebrospinal fluid shunting is the mainstay of treatment but carries a risk of overdrainage, l...
S. Frome, Daniel N. de Souza, Amogh Iyanna et al.· Neurosurgery· 0 citations
The etiology of hydrocephalus in patients with mass lesions is heterogeneous and endoscopic management is successful in patients with obstructive hydrocephalus if their tumors do not have a propensity for leptomeningeal disease, such as high-grade gliomas or CNS lymphoma.
Ryan M. Hess, D. Ormond· Journal of Neurosurgery· 0 citations
A practical checklist for neurology and neurosurgery that balances beneficence with nonmaleficence, advances equity for geriatric populations, preserves the possibility of substantial functional recovery, and honors both patient autonomy and responsible resource stewardship is proposed.
K. Iserson· Journal of Clinical Ethics· 0 citations
Surgically inoperable cerebral arteriovenous malformations (AVMs), including deep-seated, large, and eloquently located lesions, remain difficult to manage because the cumulative risk of hemorrhage must be balanced against the morbidity of curative microsurgery. Contemporary stereotactic radiosurgery (SRS) has expanded...
Shinya Yuki, Dong-Hoon Lee, Yusuke S. Hori et al.· Journal of clinical neurosci...· 0 citations
Background and Objectives There is ongoing clinical equipoise regarding the optimal treatment strategy for symptomatic cerebral cavernous malformations (CCMs). The aim of this study was to estimate the causal effect between CCM intervention (microsurgical resection or stereotactic radiosurgery) and clinical outcomes du...
Abel Clemens Adriaan Sandmann, D. Verbaan, J. Coutinho et al.· Neurology· 0 citations
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