Author

Atsushi Kuno

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Oct 2026

SIRT1 Regulates Late Stage of Autophagy and Mitophagy via Autophagosome–Lysosome Fusion in Cardiomyocytes

Sirtuin‐1 (SIRT1) is an NAD+‐dependent deacetylase implicated in autophagosome formation; however, whether SIRT1 also regulates autophagosome clearance during late‐stage autophagy remains unclear. Here, we investigated the role of SIRT1 in autophagosome clearance during autophagy and mitophagy in cardiomyocytes. Mitoch...

Atsushi Kuno, Yukika Saga, R. Hosoda et al. · The FASEB Journal · 0 citations

Open access Aug 2026

Activation of the NAD⁺–Sirtuin Axis Protects Against Chronic Doxorubicin-Induced Subclinical Renal Tubular Injury Through Restoration of Mitochondrial Homeostasis and Suppression of Inflammation

Background and purpose Anthracyclines, such as doxorubicin (DOX), are associated with late-onset kidney dysfunction; however, the mechanisms underlying chronic tubular injury remain poorly understood. We investigated whether chronic low-dose DOX exposure induces persistent mitochondrial dysfunction in renal tubules and...

Keiji Saito, R. Hosoda, Ryo Numazawa et al. · bioRxiv · 0 citations

Review Jul 2026

Can stereotactic radiosurgery treat idiopathic normal pressure hydrocephalus? literature-based evidence

This review examines the biological rationale, experimental evidence, and potential clinical applicability of radiosurgical ablation of the choroid plexus for iNPH to determine the feasibility and efficacy of SRS as a potential non-invasive therapeutic option for iNPH.

M. Izhar, Yusuke S. Hori, K. Abe et al. · Neurosurgical review · 0 citations