It is revealed that the MCC may act as a key metabolic pathway for propionate detoxification in M. kansasii, and the successful generation of mutants indicates that CRISPR-Cas9 is an effective approach for genetic manipulation in this species.
It is demonstrated that MxtR/ErdR directly regulates the methylcitrate cycle and coordinates both acetate and propionate metabolism, identifying this signaling system as a central regulator of SCFA homeostasis in P. alloputida KT2440.
F. Burr, T. Henríquez, Michelle Eder et al.· bioRxiv· 0 citations
The genome-wide analysis revealed extensive FtcR-binding sites throughout the B. melitensis 16M genome, including the identification of glnB as a novel target, which suggests FtcR plays a direct role in modulating nitrogen, carbon, and energy metabolism under prolonged nutrient starvation.
Yi-Dan Zhang, Yu Zhang, Sheng-Nan Song et al.· Microorganisms· 0 citations
The adaptive laboratory evolution of the F30T strain demonstrated that adaptive laboratory evolution is a highly effective strategy for enhancing the formate utilization and stress tolerance of Clostridium sp.
Soo Jae Kwon, Seongeun Yang, Sung-Mok Lee et al.· Biotechnology for Biofuels a...· 0 citations
The plasmid-free system constructed in this study effectively avoids the plasmid-induced metabolic burden and genetic instability and demonstrates the prominent advantages and great application potential of plasmid-free modular engineering for the efficient biosynthesis of OSH and other high-value amino acids.
Si-Min Huang, Xu He, Ruo-Nan Wang et al.· Journal of Biotechnology· 0 citations
Summary Several Mollicutes species import glycerol and related molecules as carbon sources, resulting in the release of hydrogen peroxide (H2O2), which has been suggested as a pathogenicity mechanism. We systematically deleted genes encoding components of the H2O2 pathways in Mycoplasma mycoides subsp. capri GM12 to...
Suchismita Chandran, N. González-Juarbe, N. Assad-Garcia et al.· iScience· 0 citations
ABSTRACT Mycobacterium tuberculosis (Mtb) survives host defenses by adapting to host conditions, including acid stress, during infection. A critical survival strategy involves pH homeostasis, mediated by complex signaling systems that regulate metabolic reprogramming and stress responses. While the lysine acetyltransfe...
Yi Liu, Nadia Fernandes, Valwynne Faulkner et al.· Journal of Bacteriology· 0 citations
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