Jan 2026· Rapid Communications in Mass Spectrometry· Vol 40· 0 citations· 23 references
Medicine
Abstract
Duvelisib (DVB), a selective PI3K‐δ/γ inhibitor approved for chronic lymphocytic leukemia, requires detailed metabolic characterization to support early drug development and selection of appropriate toxicology species. Because drug metabolism varies across species, an integrated system such as primary hepatocytes containing both Phase I and Phase II enzymes is critical for accurately defining metabolic pathways and identifying potential reactive metabolites.
Human evidence linking di(2-ethylhexyl) phthalate (DEHP) exposure to hepatocellular carcinoma (HCC) is limited, and it remains unclear whether DEHP-relevant detoxification biology captures clinically meaningful HCC heterogeneity.
We integrated two-sample Mendelian randomization, proteomic and phosphoproteomi...
Ze-Yang Fan, Guo-Qing Zhang, Le-Tian Ren et al.· Frontiers in Toxicology· 0 citations
The total saponins from Celosiae Semen (TSCS) show hepatoprotective and lipid-lowering effects against metabolic dysfunction-associated steatotic liver disease (MASLD). However, their in vivo metabolic fate and holistic pharmacokinetic (PK) features remain largely uncharacterized. In this study, an integrated PK-marker...
Chun-Lu Liu, Lu-Lu Yang, Song Fan et al.· Journal of Pharmaceutical an...· 0 citations
BACKGROUND
Prothioconazole (PTC) is one of the most widely used triazole fungicides worldwide, while its major metabolite, prothioconazole-desthio (dPTC), exhibits enhanced toxicological potential. However, the metabolic perturbations induced by chronic PTC exposure and sensitive biomarkers for exposure monitoring rema...
Lin-Lin Shi, Wen-Hui Li, Xian-Dan Zhu et al.· Pest Management Science· 0 citations
Bortezomib (BTZ), a first-generation proteasome inhibitor, serves as a cornerstone chemotherapeutic agent for Multiple Myeloma (MM), with its clinical application in oncology expanding rapidly in recent years. Using vascular-specific transgenic zebrafish models, we systematically evaluated BTZ-induced toxicity at 4–5 m...
Yu-Lian Li, Si Dong, Hao Cheng et al.· Fluids and Barriers of the C...· 0 citations
Novel guaianolide sesquiterpenoid CI was identified as an affinity-dependent dual-target regulator of STK11 and PP2Ac α with low affinity to inhibit AMPK activation to alleviate DILI.
Fei Zhou, Yu Liu, Hao-Yu Zhao et al.· Journal of Advanced Research· 0 citations
Hydatid cyst fluid (HCF) is a biochemically complex parasite-derived mixture whose effects on host and cancer cells are highly context dependent. The aim of this study was to determine whether short-term exposure to bovine liver- or lung-derived HCF alters Caco-2 XTT-based viability/metabolic activity and to characteri...
M. Nenni, M. Çelebier, S. Maçin et al.· Experimental parasitology· 0 citations
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