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Duvelisib (DVB), a selective PI3K‐δ/γ inhibitor approved for chronic lymphocytic leukemia, requires detailed metabolic characterization to support early drug development and selection of appropriate toxicology species. Because drug metabolism varies across species, an integrated system such as primary hepatocytes conta...
Four new series of tetrazole annulated benzopyridodiazepine derivatives are synthesized, especially 14h, which shows significant inhibition of TrkB in neuroblastoma cells, indicating that the tetrazole annulated benzopyridodiazepine is an interesting molecule for exploration in the management of cancer and neurological...
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