Enhanced antibacterial and anti-biofilm activity of PEGylated niosomes co-loaded with nisin and ZnO nanoparticles against VRSA and ceftazidime-resistant Pseudomonas aeruginosa
PEGylated niosomal co-delivery of Nis and ZnO nanoparticles provides a potent, broad-spectrum, and biocompatible strategy to combat multidrug-resistant bacteria and disrupt biofilms, supporting its potential for further in vivo evaluation.
These proof-of-concept findings indicate that C. verum-mediated Fe₂O₃-NPs show potent in vitro multi-mechanism antibacterial activity against two clinically confirmed CRE UPEC isolates, combining promising antibacterial potency with transcriptional suppression of key virulence determinants.
Ahmed Abass Fadel, K. H. Alobaidi, J. Al-Obaidi· International Microbiology· 0 citations
Methicillin-resistant Staphylococcus aureus (MRSA) infections remain a major public health challenge because of limited therapeutic options and the increasing prevalence of multidrug resistance. In this study, carrier-free quercetin-zinc supramolecular assemblies (Qct-Zn NPs) were fabricated through coordination-associ...
Ying Chen, Xiu-Zhen Chen, Wei-Xiao Wang et al.· Frontiers in Microbiology· 0 citations
Nisin-loaded niosomes are promising therapeutic method for the controlling of Gram-negative UTIs in clinical and veterinary settings and their antibacterial activity was evaluated against clinical and veterinary isolates.
S. Rashed, Ammar R. Algburi, Razieh Niazmand et al.· Diyala Journal for Veterinar...· 0 citations
Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of healthcare-associated mortality, with multidrug resistance and biofilm formation limiting treatment options. Anti-virulence strategies targeting adhesin gene expression offer a promising alternative, yet the ability of green-synthesised ZnO-NPs to s...
A. Nasser, K. H. Alobaidi, J. Al-Obaidi· International Microbiology· 0 citations
Abstract Carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a major therapeutic challenge due to antimicrobial resistance and biofilm formation. This study developed chitosan-coated meropenem-loaded niosomes (Nio-MRP@CS) and evaluated their physicochemical properties and antibacterial, antibiofilm, and gene-modula...
F. Ashrafi, G. Khalili, P. Moulavi et al.· Journal of Microencapsulatio...· 0 citations
Background: Biofilms formed by Staphylococcus aureus display marked tolerance to conventional antibiotic therapy, which contributes to the persistence of chronic infections and complicates their clinical management. There is therefore a pressing need to develop alternative delivery strategies capable of penetrating the...
Kamalesh Pandidurai, Baby Roselin Rajandurai, Justin Anthony et al.· Biomedical Engineering Commu...· 0 citations
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