TL;DR
A novel hydrogel kit integrating photonic crystals (PCs) and DNA-AgNCs for portable detection of miRNA-21 facilitates facile miRNA-21 detection, overcomes the drawbacks of conventional approaches, and holds considerable promise for clinical tumor diagnostic applications.
A dual-mode fluorescence-colorimetric biosensing platform for the ultrasensitive detection of miRNA-21, integrating AuNP-supported dual-stage rolling circle amplification (RCA) with an RCA-generated multipedal binding-and-cleavage mechanism, demonstrating excellent specificity and distinguished the endogenous responses...
A highly efficient signal-transduction strategy utilizing Fe-coordinated DNA nanospheres (FDNSs)─a programmable, metal-nucleic acid assembly─as a high-capacity DNA reservoir for amplified biomarker sensing, providing a robust and portable solution for cancer screening in resource-limited settings.
MicroRNAs (miRNAs) are crucial regulators in tumor development, so accurately detecting and imaging them in living cells is vital for early cancer diagnosis. However, their low levels inside cells and the complex cellular environment make traditional detection methods challenging. We developed a fluorescent sensing pla...
The accurate detection of liver cancer-associated microRNAs (miRNAs) remains challenging due to their low abundance and high sequence homology. Herein, we report a colorimetric biosensor integrating Exo-III-assisted target recycling with a cyclization-functional DNAzyme walker for sensitive and highly specific miRNA de...
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