Aug 2026· Journal of Functional Biomaterials· 0 citations· 211 references
TL;DR
Pure and hybrid DNA hydrogels are proposed as novel therapeutic platforms to restore the dynamic balance between bone resorption and formation, thereby enhancing osteogenesis and facilitating bone regeneration and remodeling under osteoporotic conditions.
Abstract
DNA hydrogels are an emerging class of biomaterials with programmability, biodegradability, biocompatibility, and dynamic responsiveness, enabling precise regulation of osteoblast and mesenchymal stem cell (MSC) proliferation and differentiation, activation of key signaling pathways, and promotion of angiogenesis and bone matrix mineralization. In contrast, conventional bone repair materials exhibit limitations including poor mechanical strength, uncontrollable degradation, and inadequate matching with native bone properties, restricting their application in osteoporotic defect repair. Current osteoporotic defect therapies, mainly anti-resorptive and anabolic agents, remain insufficient for many patients. Here, we propose pure and hybrid DNA hydrogels as novel therapeutic platforms to restore the dynamic balance between bone resorption and formation, thereby enhancing osteogenesis and facilitating bone regeneration and remodeling under osteoporotic conditions. Although challenges such as high production cost and long-term safety persist, integration with advanced technologies (e.g., 3D printing and gene editing) may provide theoretical support for further investigation of personalized and intelligent therapeutic strategies at the pre-clinical research stage, offering new insights into osteoporotic bone defects and bone tissue regeneration.
It is argued that formation of a tumour-intrinsic niche is a prerequisite for BRAF-mutant CRC seeding to distant organs and that interference with niche formation may help avoid metastatic relapse.
J. Bugter, L. El Bouazzaoui, E. Küçükköse et al.· bioRxiv· 2 citations
It is concluded that bridging the gap between foundational CRISPR research and its real-world applications is imperative and future efforts should focus on democratizing tools via open-source platforms, advancing delivery systems, and fostering sustainable innovation through synthetic biology integration to fully realize the transformative potential of genome editing in organisms beyond model organisms.
S. Sarsaiya, Archana Jain, Jishuang Chen et al.· Biotechnology Advances· 2 citations
Global agriculture faces a 2050 "perfect storm": rising temperatures, elevated CO2, and compound climate stresses – heatwaves, flash droughts, and floods – that cause non-linear yield losses. The Green revolution paradigm of maximizing yield potential (Yp) is no longer sufficient. We argue that the primary breeding target must shift decisively to yield stability (Ys): consistent performance across volatile and non-analog environments. Unlike prior trait-focused reviews that catalog physiological mechanisms without breeder-ready deployment tools, here we provide a breeder-ready roadmap of 20 keystone physiological traits, each with its genetic target, validated marker, donor germplasm, heritability, yield penalty, and deployment timeline. Traits such as SUB1A (submergence), HKT1;5 (salt exclusion), and DRO1 (deep rooting) are ready for immediate marker-assisted introgression. We highlight that the time and cost for modern breeding methods are reducing i.e., marker-assisted backcrossing (2–3 years; $1.50–$5.00 per marker), genomic selection (3–5 years; $15–$40 per sample), and speed breeding (reducing cycles by up to 60%). Critically, the regulatory landscape is diverging while the United States maintains a streamlined, notification-only process for transgene-free edits, the European Union has recently adopted a new framework (April 2026) that classifies gene-edited plants into two categories, aiming to reduce the historic $15M+ barrier for category-1 equivalents. This roadmap is distinctive in its direct translation of 100 physiological traits into 20 deployable keystone targets, with explicit genetic resources, cost timelines, and regulatory pathways, making it an actionable plan rather than a theoretical framework. We conclude with time-bound milestones: universal genotyping for all MAS-ready traits by 2030, harmonization of global regulatory pathways by 2035, and broad-scale genomic prediction deployment by 2040. The roadmap is not merely a beginning; it is an actionable plan for global food security.
M. A. Nawaz, K. Golokhvast· Integrative Plant Biotechnol...· 0 citations
The exogenous addition of xylose as a signal to initiate genetic editing achieved the spatiotemporal regulation of the target gene-activating gene editing that restricts growth only after the completion of the strain's growth phase, and raised the total pigment yield.
Jiawen Du, Long-Xiang Liu, Jiawen Gao et al.· Bioresource Technology· 0 citations
This review summarizes the trajectory of iPSC reprogramming technologies and identifies the core “translational triltrilas”, namely, the inherent tradeoffs between security, homogeneity, and scalability, and proposes a comprehensive strategy to overcome these bottlenecks.
Mengmeng Chen, Ning Zuo, Qi Wang et al.· Frontiers in Cell and Develo...· 0 citations
A new method for surgically removing training examples from a model reveals that as datasets grow, the link between what a model learns and what it produces dissolves.
MIT News · Artificial Intelligence· news.mit.eduAug 17, 2026
