Alveolar ridge preservation using an intentionally exposed xenogeneic collagen matrix seal in sockets with varying proportions of vertical bone resorption: a pilot study.

Effect of Titanium-Prepared Platelet-Rich Fibrin on Extraction Socket Preservation: A CBCT-Based Volumetric Analysis

Objective: Alveolar ridge remodeling following tooth extraction may compromise subsequent implant placement. Titanium-prepared platelet-rich fibrin (T-PRF) has been proposed as an autologous biomaterial that may enhance socket healing and minimize post-extraction dimensional changes. This study aimed to compare the radiographic healing of extraction sockets treated with T-PRF and those left to heal spontaneously using cone-beam computed tomography (CBCT)-based volumetric analysis. Methods: A total of 30 systemically healthy patients (18 males and 12 females) requiring tooth extraction followed by implant placement were enrolled in this randomized clinical trial. A total of 58 extraction sockets were included, with 27 sockets allocated to the T-PRF group and 31 sockets assigned to spontaneous healing (control group). The initial CBCT examination (baseline assessment) was performed 7–10 days after tooth extraction, and a follow-up CBCT examination was performed 3 months after extraction. Baseline socket volume, residual non-ossified socket volume, and the estimated percentage of socket fill were assessed using dedicated volumetric analysis software. Because some participants contributed more than one extraction socket, generalized estimating equations (GEE) were used to account for within-patient clustering. Results: Baseline socket volumes were comparable between the groups (p = 0.752). At 3 months, the residual non-ossified socket volume was significantly lower in the T-PRF group than in the control group (0.043 cm³ vs. 0.087 cm³; p = 0.013). Both groups demonstrated progressive socket healing over time; however, the estimated percentage of socket fill was significantly higher in the T-PRF group than in the control group (80.1% vs. 57.3%). Conclusion: Within the limitations of this randomized clinical trial, T-PRF was associated with improved radiographic healing of extraction sockets, as reflected by a lower residual non-ossified socket volume after 3 months compared with spontaneous healing. T-PRF may represent a simple, autologous, and clinically useful adjunct for socket preservation prior to implant placement.

Effect of reactive soft tissue combined with injectable platelet-rich fibrin for alveolar ridge preservation in severe defect molar sites: a retrospective cohort study

Comparative Evaluation of Bone Ring versus Particulate Bone Graft using CBCT in Buccal Bone Augmentation with Simultaneous Implant Placement: A Randomised Controlled Trial

The Bone Ring Technique (BRT) is a newer viable option for restoring complex defects around dental implants with three-dimensional bone augmentation with significant height and width augmentation of buccal bone.

Histological and radiographic evaluation of bone formation following alveolar ridge preservation using octacalcium phosphate collagen composite: A prospective non-randomized controlled clinical trial

To radiographically and histologically evaluate bone formation following alveolar ridge preservation (ARP) using octacalcium phosphate collagen composite (OCP/Col). A total of 42 patients (48 sites) completed the study. The primary comparison was performed between an OCP/Col-treated molar group (OCP-M) and an atelocollagen-treated molar control group (Control-M). In addition, an OCP/Col-treated incisor–premolar group (OCP-IP) was included as an exploratory subgroup to assess tooth-type effects. Alveolar bone dimensional changes were assessed using cone-beam computed tomography (CBCT) immediately after ARP and at 6 months. Guided hard tissue biopsies were performed to quantify the proportions of mature bone and residual granules. Changes in buccal bone height were + 0.7 mm (± 2.2) in the OCP-M group, − 0.6 mm (± 0.7) in the Control-M group, and + 3.7 mm (± 3.9) in the OCP-IP group. The difference between the OCP-M and Control-M groups was significant (p = 0.041), as was that between the OCP-IP and OCP-M groups (p = 0.038). Histologically, the proportion of mature bone in the alveolar crest region was significantly higher in the OCP-M group (38.14% ± 20.96) than in the Control-M group (18.28% ± 16.52, p = 0.009). Within the limitations of this study, ARP using OCP/Col resulted in increased buccal bone height and enhanced bone maturation at the alveolar crest compared with atelocollagen alone. OCP/Col may serve as a stand-alone graft material for ARP and may facilitate minimally invasive, prosthetically driven implant therapy. UMIN000059637 (UMIN Clinical Trials Registry).

Cleft Alveolar Bone Grafting Using Mandibular Symphyseal Bone Graft and Resorbable Collagen Membrane: A CBCT-Based 3-Dimensional Morphometric Analysis.

ObjectiveIliac cancellous bone graft has been regarded as the gold standard for secondary alveolar bone grafting (SABG); however, it is associated with a high resorption rate and donor-site morbidity. This study aimed to evaluate the radiographic outcomes of SABG using a mandibular symphyseal bone graft combined with a double-layer resorbable collagen membrane through standardized 3-dimensional cone-beam computed tomography (CBCT)-based morphometric assessment.DesignRetrospective study.SettingPatients with unilateral cleft lip/palate (UCLP) or bilateral CL/P (BCLP) who underwent SABG at a single center.Patients and InterventionEighteen patients with UCLP/BCLP who underwent SABG using a mandibular symphyseal bone graft and a double-layer resorbable collagen membrane between 2022 and 2025.Main Outcome MeasuresPreoperative and 1.5-year postoperative CBCT-based 3-dimensional linear morphometric measurements, including cleft width reduction and postoperative bone bridge thickness.ResultsAt 1.5 years postoperatively, cleft width significantly reduced at all measurement levels (P < .001). The mean postoperative bone bridge thickness was 5.97 ± 2.02 mm at the mid-root level and 6.62 ± 2.50 mm at the apical level.ConclusionsMandibular symphyseal bone grafting combined with a double-layer resorbable collagen membrane yielded favorable radiographic outcomes, with substantial reduction of alveolar cleft defects and satisfactory bone bridge formation in this retrospective cohort. This technique may be a viable treatment option for selected patients. However, prospective controlled studies with larger cohorts and longer follow-up are needed to confirm its comparative effectiveness and long-term stability.

Membrane-free guided tissue regeneration with enamel matrix derivative and bone graft materials improves 3-dimensional periodontal outcomes in small dogs.

Objective To evaluate the clinical and radiographic outcomes of membrane-free guided tissue regeneration (GTR) using enamel matrix derivative (EMD) with bone grafts in dogs with vertical infrabony periodontal defects. Methods This retrospective study reviewed cases of client-owned dogs that underwent membrane-free GTR using EMD in combination with bone grafts between August 1, 2023, and September 30, 2025. Outcomes were assessed from records and cone-beam computed tomography (CBCT) datasets using 2-D measurements of clinical attachment loss (CAL) and vertical bone defect ratio (VBDR) and 3-D volumetric analysis. Success was defined as CAL improvement (≥ 1 mm) and VBDR reduction (> 10%). Volumetric analysis was used to quantify infrabony defect fill. Results 20 periodontal defects in 16 dogs were included (allograft, n = 10; xenograft, 10). Median follow-up was 7 months (range, 6 to 14 months). All defects met the success criteria. Median CAL decreased from 5.0 mm (range, 3.0 to 8.0 mm) to 2.0 mm (range, 1.0 to 3.0 mm), and median VBDR decreased from 0.42 (range, 0.16 to 0.78) to 0.18 (range, 0.04 to 0.46). Volumetric analysis revealed a median infrabony defect fill of 98.49% (range, 71.86% to 100.00%). Conclusions Membrane-free GTR with EMD was associated with clinically meaningful periodontal improvement and substantial infrabony defect fill in appropriately selected canine patients with vertical infrabony defects. Prospective, controlled studies are warranted to further evaluate its efficacy and indications. Clinical Relevance This membrane-free regenerative approach may provide a practical tooth-preserving treatment option for selected small-breed dogs when conventional barrier-membrane placement is technically challenging.