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#gene editing Review Sep 2026

Unlocking non-model organisms with CRISPR-Cas: A roadmap for sustainable biotechnology.

It is concluded that bridging the gap between foundational CRISPR research and its real-world applications is imperative and future efforts should focus on democratizing tools via open-source platforms, advancing delivery systems, and fostering sustainable innovation through synthetic biology integration to fully realize the transformative potential of genome editing in organisms beyond model organisms.

S. Sarsaiya, Archana Jain, Jishuang Chen et al. · 2 citations
#gene editing Aug 2026

CRISPR/Cas9-Mediated Site-Directed Mutagenesis of Genes in Klebsiella pneumoniae.

This protocol minimizes off-target editing, shortens experimental timelines, reduces screening workload, and provides a reliable platform for investigating resistance mechanisms, validating candidate genes, and supporting functional genomics studies in clinically relevant bacterial pathogens.

Liu Chun, Zhang Quan, Matas Ke · 0 citations
#gene editing Review Open access Aug 2026

100 Traits, 20 Keystone, 1 Goal: Yield Stability for 2050

Global agriculture faces a 2050 "perfect storm": rising temperatures, elevated CO2, and compound climate stresses – heatwaves, flash droughts, and floods – that cause non-linear yield losses. The Green revolution paradigm of maximizing yield potential (Yp) is no longer sufficient. We argue that the primary breeding target must shift decisively to yield stability (Ys): consistent performance across volatile and non-analog environments. Unlike prior trait-focused reviews that catalog physiological mechanisms without breeder-ready deployment tools, here we provide a breeder-ready roadmap of 20 keystone physiological traits, each with its genetic target, validated marker, donor germplasm, heritability, yield penalty, and deployment timeline. Traits such as SUB1A (submergence), HKT1;5 (salt exclusion), and DRO1 (deep rooting) are ready for immediate marker-assisted introgression. We highlight that the time and cost for modern breeding methods are reducing i.e., marker-assisted backcrossing (2–3 years; $1.50–$5.00 per marker), genomic selection (3–5 years; $15–$40 per sample), and speed breeding (reducing cycles by up to 60%). Critically, the regulatory landscape is diverging while the United States maintains a streamlined, notification-only process for transgene-free edits, the European Union has recently adopted a new framework (April 2026) that classifies gene-edited plants into two categories, aiming to reduce the historic $15M+ barrier for category-1 equivalents. This roadmap is distinctive in its direct translation of 100 physiological traits into 20 deployable keystone targets, with explicit genetic resources, cost timelines, and regulatory pathways, making it an actionable plan rather than a theoretical framework. We conclude with time-bound milestones: universal genotyping for all MAS-ready traits by 2030, harmonization of global regulatory pathways by 2035, and broad-scale genomic prediction deployment by 2040. The roadmap is not merely a beginning; it is an actionable plan for global food security.

M. A. Nawaz, K. Golokhvast · 0 citations
#gene editing Aug 2026

The spatiotemporal-specific regulation of cell wall-related proteins promotes the secretion of pigments in Antarctic fungi Geomyces sp. wnf-18c.

The exogenous addition of xylose as a signal to initiate genetic editing achieved the spatiotemporal regulation of the target gene-activating gene editing that restricts growth only after the completion of the strain's growth phase, and raised the total pigment yield.

Jiawen Du, Long-Xiang Liu, Jiawen Gao et al. · 0 citations
#gene editing Review Open access Aug 2026

Induced pluripotent stem cell reprogramming: methodological evolution and challenges in clinical translation

This review summarizes the trajectory of iPSC reprogramming technologies and identifies the core “translational triltrilas”, namely, the inherent tradeoffs between security, homogeneity, and scalability, and proposes a comprehensive strategy to overcome these bottlenecks.

Mengmeng Chen, Ning Zuo, Qi Wang et al. · 0 citations

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