Jul 2026· Cancer Biology and Medicine· Vol 23, pp. 1004 - 1015· 0 citations· 28 references
Medicine
TL;DR
Risks were stable before 40 years of age, peaked in middle age, and declined after 70 years of age, and residual risk gradually decreases with age.
Abstract
Objective: Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related mortality worldwide. This study was aimed at estimating regional and national variations in lifetime CRC risk worldwide. Methods: CRC data were extracted from GLOBOCAN 2022, including 185 countries, and population and all-cause mortality data were sourced from the United Nations. The world was divided into 20 geographical regions and categorized by Human Development Index (HDI). Lifetime CRC risk was estimated with the life table method, adjusted for multiple primary cancers. Results: In 2022, the lifetime risks of developing and dying from CRC were 2.69% [95% confidence interval (CI): 2.68–2.70] and 1.39% (95% CI: 1.39–1.40), respectively. Men had a higher risk of colon cancer than rectal cancer, and higher CRC risk than women. Lifetime risk varied by region and HDI: regions with very high, high, moderate, and low HDI had incidence risks of 5.17%, 2.75%, 0.72%, and 0.57%, respectively, and mortality risks of 2.48%, 1.50%, 0.44%, and 0.41%, respectively. Australia/New Zealand had the highest incidence risk (7.41%, 95% CI: 7.30–7.52), and Northern Europe the highest mortality risk (3.28%, 95% CI: 3.24–3.32). Risks were stable before 40 years of age, peaked in middle age, and declined after 70 years of age. Temporally, Thailand had the highest increasing trend in lifetime risk, whereas the United States and Austria showed a decreasing trend. Conclusions: Lifetime CRC risk differs by subtype, sex, HDI, and geography, and residual risk gradually decreases with age. Targeted primary prevention strategies should be implemented in various countries and regions to mitigate CRC burden.
The findings suggest that socioeconomic and environmental factors may be associated with regional disparities in lung cancer burden and could offer insights for targeted prevention policies, including smoking control and air quality management.
Jiawei Zhai, Hui-Juan Zheng, Lan-Gang Xue· Frontiers in Public Health· 0 citations
Substantial geographic and socioeconomic disparities exist in respiratory cancer lifetime risk, with lung cancer as the dominant driver, and the observed ecological associations with air pollutants support further investigation of environmental factors in cancer prevention.
Meng Jiang, Yu Qian, Qilong Wang et al.· Preventive medicine reports· 0 citations
The prevalence of gastric cancer (GC) in China, India, and the USA has different epidemiology, but comparative analyses with regard to their time trends and causes are underdeveloped. Using the 2023 Global Burden of Disease (GBD) database (1990–2023), we evaluated GC trends via Joinpoint regression. Das Gupta decomposition and comparative risk assessment quantified demographic/epidemiological drivers and behavioral risks. ARIMA models projected the burden through 2040. Globally, gastric cancer age-standardized incidence rates (ASIR) declined from 26.31 to 14.00 per 100,000 between 1990 and 2023, whereas absolute incident cases increased from 1.05 to 1.28 million. China maintained the highest disease burden in 2023 (ASIR: 25.04/100,000) despite achieving the steepest reductions in age-standardized incidence, mortality, and DALY rates. India demonstrated the slowest decline in age-standardized rates, while incident cases nearly doubled from 42,800 to 85,400 during the study period. Joinpoint analysis identified significant upward ASIR trends after 2020 in China (APC = 3.62) and globally (APC = 1.61). Smoking remained the leading attributable risk factor, particularly in China. Decomposition analysis showed that population aging and growth were the principal drivers of increasing absolute burden. ARIMA projections suggested that China will continue to carry the highest gastric cancer burden through 2040. Despite declining standardized rates, population aging and growth continue to drive absolute case numbers upward. To mitigate this evolving burden, China requires optimized early screening and stringent behavioral risk control; India needs expanded cancer registry coverage and equitable rural healthcare access; while the USA should prioritize targeted strategies to mitigate internal disparities among subpopulations.
Feng Lin, Xue-Ying Wei, Li-Huan Song et al.· Discover Oncology· 0 citations
The study indicates that skin cancer remains an important public health issue worldwide and countries and regions should attach great importance to the prevention and treatment of skin cancers, and develop and improve preventive measures.
Cancer mortality in Alagoas is increasing steadily, characterized by premature deaths, geographic concentration, and care displacement, and decentralizing the oncology network, expanding screening for preventable tumors, and strengthening home palliative care are priority actions to reduce mortality.
Marianna Victória, C. Rocha, Adriana Martins da Conceição et al.· 0 citations
This review identifies barriers to effective disease management and discusses the current and future cancer burden across the African continent for non-specialist readers and those seeking to understand oncological care in Africa.
C. Kimwele, Catherine Kaluwa, A. Nyongesa et al.· Cancer Plus· 0 citations
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