The burden of male breast cancer (MBC) in the GBD Central, Eastern, and Western Europe Regions from 1990 to 2023: Results from the Global Burden of Disease Study 2023

Evolving burden of pancreatic cancer in the Middle East and North Africa Region, 1990–2023: an analysis based on the Global Burden of Disease Study 2023

Background Pancreatic cancer is a highly lethal malignancy characterized by an aggressive biological behavior and a narrow therapeutic window, making it a significant public health challenge. In the Middle East and North Africa (MENA) region, monitoring the evolving disease burden is essential for identifying high-risk populations and guiding the allocation of resources for early detection and palliative care. This study provides a longitudinal examination of pancreatic cancer prevalence, mortality, and disability-adjusted life years (DALYs) across the region from 1990 to 2023. Methods Using data from the Global Burden of Disease (GBD) 2023 study, we analyzed the burden of pancreatic cancer across 21 MENA countries. The primary outcomes were age-standardized prevalence, mortality, and DALY rates per 100,000 population. All estimates were age-standardized using the GBD world standard population to ensure comparability. Trends were assessed regionally, sub-regionally, and by sex from 1990 to 2023, with 95% uncertainty intervals (UIs) reported. Results The overall regional age-standardized prevalence of pancreatic cancer increased by 55.9% from 1990 to 2023, rising from 2.38/100,000 to 3.71/100,000. In terms of sex-specific prevalence rates, men had an overall age-standardized prevalence of 4.45/100,000, whereas women had an overall age-standardized prevalence rate of 2.97 per 100,000 in 2023. The same 55.3% increase trend is evidenced by the regional DALY rates (81.82 to 127.07/100,000). When considering rates of prevalence and DALYs by country, there was considerable variability. Egypt and Iraq had the most rapid increases in prevalence of pancreatic cancer (with Egypt’s prevalence being a staggering 238%), while Turkey and Lebanon had the highest overall burdens of pancreatic cancer, and the UAE and Qatar had the largest decreases of prevalence (i.e., UAE dropping by 48%). Afghanistan and Yemen had steady increases in pancreatic cancer since beginning with low rates from 1990. Conclusions The rapidly increasing burden of pancreatic cancer in the MENA region, largely driven by metabolic risk factors and an aging population, necessitates targeted public health strategies. Regional policy should prioritize aggressive primary prevention, specifically tobacco control and metabolic health, alongside the expansion of palliative care services. Furthermore, establishing robust, unified regional cancer registries is critical to improving surveillance and informing health planning.

Using the

Global burden of skin cancers and trends from 1990 to 2021: An observational study based on secondary analysis of GBD 2021

The study indicates that skin cancer remains an important public health issue worldwide and countries and regions should attach great importance to the prevention and treatment of skin cancers, and develop and improve preventive measures.

Global Dual Incidence‐Mortality Patterns of Prostate Cancer Across SDI Regions, 1990–2021: A Cross‐Sectional Study Based on Global Burden of Disease 2021

To facilitate the development of precision prevention and control measures, this research offers a comprehensive evaluation of the global prostate cancer landscape, with a specific focus on its incidence, mortality rates, and underlying risk factors.

Prognostic impact of time from diagnosis to start of radiotherapy in anal cancer

A prolonged time from diagnosis to start of radiotherapy (TTRT) for malignant disease may negatively influence survival, but studies in squamous cell carcinoma of the anus (SCCA) are largely lacking. The purpose of this study was to investigate the impact of TTRT on overall survival (OS) and anal cancer‐specific survival (ACSS) in a nationwide population‐based cohort from the Swedish Anal Cancer Registry.

Burden of Mesothelioma in China, 1990–2023: Trends, Decomposition, and Projections Until 2045

Simple Summary From 1990 to 2023, China’s mesothelioma burden rose sharply, with cases up 189% and deaths up 142%, mainly affecting older males. While age-standardized death and disability rates stabilized or fell, population growth and aging drove the overall increase, and deaths are projected to keep rising through 2045. The study calls for better asbestos surveillance, diagnostics, and cancer care to reduce future impact.