Open access
MSRB3 promotes gastric cancer progression and immunotherapy resistance by stabilizing GPX4 to inhibit ferroptosis
Jian-Qin Lai
Tai-Wei Mo
Jin-Xuan Su
Zhi-Jing Zhang
X. Zhou
Cheng-Xing Wang
Qiu-Ming Zou
Si-Jia Li
Xiao-Song Zhuang
Fang-Yuan Chen
Qing Huang
Jie Cao
Abstract
Highlights • MSRB3 is overexpressed and predicts poor prognosis in gastric cancer.• MSRB3 suppresses ferroptosis by stabilizing GPX4 protein.• MSRB3 inhibits GPX4 ubiquitination and proteasomal degradation.• MSRB3 depletion increases CD8+ T-cell infiltration in tumors.• Targeting MSRB3 enhances response to anti-PD-1 immunotherapy.