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Cheng-Xing Wang

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Open access Oct 2026

MSRB3 promotes gastric cancer progression and immunotherapy resistance by stabilizing GPX4 to inhibit ferroptosis

Highlights • MSRB3 is overexpressed and predicts poor prognosis in gastric cancer.• MSRB3 suppresses ferroptosis by stabilizing GPX4 protein.• MSRB3 inhibits GPX4 ubiquitination and proteasomal degradation.• MSRB3 depletion increases CD8+ T-cell infiltration in tumors.• Targeting MSRB3 enhances response to anti-PD-1 im...

Jian-Qin Lai, Tai-Wei Mo, Jin-Xuan Su et al. · 0 citations

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