Vinpocetine attenuates myocardial ischemia/reperfusion injury in mice by suppressing oxidative stress, inflammation, and apoptosis.

Flurbiprofen axetil attenuates myocardial ischemia-reperfusion injury and suppresses NLRP3 inflammasome signaling.

Isolinderalactone alleviates hepatic ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress through the SIRT1/IRE1α signaling pathway.

ILL attenuates HIRI by simultaneously elevating SIRT1 expression and activating its deacetylase function, thereby restraining IRE1α-dependent ERS and subsequent hepatic injury, highlighting ILL as a promising therapeutic candidate for the management of perioperative HIRI.

Imeglimin confers protection against intestinal ischemia/reperfusion injury in rats through AMPK-dependent inhibition of NF-κB/NLRP3 inflammasome signaling and mitigation of oxidative stress and apoptosis

IMEG exerts a protective effect against intestinal I/R injury through its antioxidant, anti-inflammatory, and anti-apoptotic properties.

Kaempferol alleviates myocardial ischemia-reperfusion injury by activating the Nrf2/GPX4 signaling pathway to inhibit ferroptosis.

It is demonstrated that kaempferol ameliorates MIRI by activating Nrf2/GPX4-related antioxidant signaling, thereby inhibiting ferroptosis, attenuating apoptosis, reducing myocardial structural damage, and ultimately preserving cardiac function.

Eucalyptol Mitigates Isoproterenol-Induced Myocardial Injury in Rats via Activation of p38 MAPK/JNK Signaling, Suppression of ER Stress, and Modulation of Apoptotic Pathway.

BACKGROUND Myocardial injury (MI), a subset of cardiovascular diseases, remains a leading cause of deaths globally, driven by pathological inflammation, oxidative stress, and apoptotic cell death. Despite advances in interventional cardiology, high relapse rates and therapeutic limitations underscore the urgent need fo...

Dexmedetomidine Alleviates Cardiomyocyte Senescence Induced by Ischemia-Reperfusion Injury via Inhibiting the MDH2/NF-κB Pathway.