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Tian-Chen Xia

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Sep 2026

Plicamycin protects against myocardial ischemia-reperfusion injury by activating the CREB-BDNF axis in mice.

Plicamycin (PLI) is a small-molecule aureolic acid antibiotic that has been approved for cancer treatment since the 1970s. However, its interaction with cardiovascular biological systems during myocardial ischemia-reperfusion injury (MIRI) remains largely unknown. This study examines its cardioprotective effects and th...

Tian-Chen Xia, Weijing Wang, Bo-Yuan Xia et al. · 0 citations
Aug 2026

Vinpocetine attenuates myocardial ischemia/reperfusion injury in mice by suppressing oxidative stress, inflammation, and apoptosis.

Observations in the current work imply that heart-protective benefits conferred by VIN occur to a substantial degree via blockade of NLRP3 inflammasome activity, in which suppression of the NLRP3 inflammasome may constitute one key pathway accounting for such beneficial outcomes.

Tian-Chen Xia, Yichen Qian, YiLong Jiang et al. · 0 citations

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