APOL1 Risk Genotypes and Sickle Cell Trait are Associated with Kidney Disease Progression in an Afro-Brazilian Population.

Assessment of TCF7L2 Gene rs7903146 Polymorphism as Type 2 Diabetes Genetic Risk  Factor within Southern Iraqi Population

Objective: To investigate the association between the TCF7L2 rs7903146 polymorphism and type 2 diabetes mellitus susceptibility in a southern Iraqi population Study Design: Case-control studyPlace and Duration of Study: This study was conducted at the Al-Fayhaa Teaching Hospital, Basrah, Iraq, from 1st November 2025 to...

Haplotype structure and functional genotype–phenotype interactions of PON1 (L55M/Q192R) variants in Egyptian children with nephrotic syndrome

Common alpha-1 antitrypsin deficiency genotypes: lung cancer risk and tumour molecular profile

Carriage of common AAT-deficient alleles was inversely associated with LC after adjustment for major confounding factors, and the association with higher PD-L1 expression suggests that these common AAT-deficient genotypes may be associated with differences in tumour phenotype rather than acting as a direct aetiological...

An integrative review of APOL1 kidney disease with a focus on the Brazilian population

Highlights • CKD remains a major health burden in Latin America and middle-income regions.• APOL1 kidney disease poses diagnostic and therapeutic challenges in admixed populations.• Studies on APOL1 kidney disease are scarce in admixed and Afro-Brazilians.• Findings support new public health strategies for Afro-Brazili...

Carriage of the Laboratory of Genetics and Physiology Protein 2 Q425R Variant Reduces Liver Disease Severity in European Patients With Chronic Hepatitis Delta.

INTRODUCTION Laboratory of genetics and physiology protein 2 (LGP2) Q425R variant enhances interferon-mediated antiviral responses in chronic hepatitis delta (CHD) in vitro. This study aimed to evaluate the association between the LGP2 Q425R variant and liver disease severity in untreated CHD patients. METHODS In tot...

Associations of PNPLA3 and TM6SF2 gene polymorphisms and systemic inflammation with MASLD severity in patients with heart failure

Objective — to evaluate the influence of PNPLA3 (rs738409) and TM6SF2 (rs58542926) allelic variants and systemic inflammation on the severity of liver steatosis, fibrosis stage, metabolic profile, and myocardial functional parameters in patients with metabolic dysfunction‑associated steatotic liver disease (MASLD) and...