The role of myeloid-derived suppressor cells in the development and control of Systemic Lupus Erythematosus

Abstract

The immune system protects the body against harmful agents and is composed of several molecules that perform this function. However, when this system attacks the body’s own cells, autoimmunity is established, as it becomes unable to distinguish self from non-self, which characterizes autoimmune diseases. Systemic lupus erythematosus (SLE) is an autoimmune disease that can present symptoms ranging from mild to severe. Myeloid-derived suppressor cells (MDSCs) are cells responsible for immunosuppression; however, under pathological conditions, they may expand and become dysfunctional. In this context, the present study aimed to explore the contribution of these cells to the pathophysiology of systemic lupus erythematosus. This study consisted of a literature review, with searches conducted in the PubMed and BVS databases, resulting in the inclusion of 15 articles. Based on the results obtained, a relevant involvement of MDSCs in the pathophysiology of SLE was observed, as in some contexts they contribute to inflammation and disease progression, whereas in others they may exert a regulatory effect. It is concluded that MDSCs play a relevant role in the pathogenesis of SLE and that further studies may reveal new therapeutic targets.