Integrated proteomic profiling and in silico miRNA and lncRNA analysis of glucose-capped fisetin silver nanoparticle-mediated cell proliferation arrest in breast cancer
GF-Ag NPs can modulate the expression of key genes and signalling pathways involved in breast cancer progression and apoptosis, suggesting that GF-Ag NPs can modulate the expression of key genes and signalling pathways involved in breast cancer progression.
Novel insights are provided into the molecular mechanism underlying ZEA-induced promotion of endometrial cancer, highlighting the potential role of miR-204 as a key mediator and contributing to understanding the role of environmental factors in cancer development.
Varsha Singh, Saria Anjum, Payal Mandal et al.· Toxicology and Applied Pharm...· 0 citations
This study identified five lung cancer-associated hub genes and provided preliminary evidence that resveratrol may modulate their expression, and provides a multi-level molecular framework for further investigation of resveratrol-responsive networks in lung cancer.
Jing-Hua Yang, Han-Xiu Wei, Jie Li et al.· Cell Biochemistry and Biophy...· 0 citations
Background/Objectives: Triple-negative breast cancer remains a major therapeutic challenge due to its aggressive behavior and limited treatment options. Methods: In this study, an integrated multi-omics strategy combining SILAC-based quantitative proteomics, shotgun lipidomics, and targeted metabolomics was applied to...
M. P. Buendia-Nacarino, Dominik Bulfon, Nikola Tom et al.· Pharmaceutics· 1 citation
Nonsmall cell lung cancer (NSCLC) remains a major cause of cancer mortality, underscoring the need for multitarget therapeutic candidates with defined mechanisms. This study investigated the anti-NSCLC activity of Zishangan Granule (ZSG), a four-herb formulation, using serum metabolomics, network pharmacology, molecula...
Muhammad Yousif, Fei Liao, Hao-An Wang et al.· Omics· 0 citations
INTRODUCTION/OBJECTIVE
Breast cancer is one of the most common malignant tumors in women worldwide, and Danggui Shaoyao San (DGSY San) is commonly used in the clinical treatment of breast cancer.
METHODS
This study integrates UHPLC-QE-MS/MS, network pharmacology, transcriptomics, and in vitro experiments to explore t...
Jing Wang, Li Zhang, Ying Yu et al.· Current Medicinal Chemistry· 0 citations
Although specific mRNAs serve as key structural hubs, hsa-miR-378c and hsa-miR-449a emerge as robust independent prognostic biomarkers, providing important insights into TNBC risk stratification and potential targeted therapeutic strategies.
Selim Öğüt, Ebru Cingöz Çapan, Günnaz Çapan et al.· Journal of clinical practice...· 0 citations
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