Jul 2026· International Journal of Biology and Life Sciences· Vol 15, pp. 90-99· 0 citations· 35 references
TL;DR
The survival analysis found that there is a relationship between the levels of AQP2 gene expression and overall survival rate of patients and AQP2 can be considered as an important marker for prognosis.
Abstract
In this research, differentially expressed genes in prostate cancer have been studied through TCGA database with the aim of elucidating on their functional features and predictive value. Differentially expressed genes (DEGs) were obtained using DESeq2 while enrichment analysis using GO and KEGG was used to examine their biological features. Survival analysis was used to determine their predictive value. It was determined that there are 123 differentially expressed genes (5 upregulated, 118 downregulated) in this cancer type. Through the enrichment analysis, it was established that these genes are mainly involved in regulation of peptidase activity, reproduction, and neuroactive ligand-receptor interactions. The survival analysis found that there is a relationship between the levels of AQP2 gene expression and overall survival rate of patients (P = 0.0098). Therefore, AQP2 can be considered as an important marker for prognosis.
The developed risk model offers valuable insights for clinical prognostic prediction and immunotherapy in KIRC and indicates an increased likelihood of immune escape in the high-risk group.
Shi-Bin Guo, Shuangqin Xu, Peng Song et al.· Medicine· 0 citations
The molecular basis of TNBC development is poorly understood. Therefore, it is of interest to identify key genes and pathways involved in TNBC development and progression using a systems biology approach, followed by experimental validation. Gene ontology and KEGG enrichment analyses were performed to identify DEG-regu...
BACKGROUND
Oral squamous cell carcinoma (OSCC) is among the most common head and neck cancers, representing about 90% of all cases. Despite advances in treatment, the prognosis remains poor, mainly owing to the complex immunosuppressive tumor microenvironment.
METHODS
The GEO2R tool was used to screen differentially...
Mohammad Hossin Shushizadeh, Niloufar Sadat Kalaki, Tahmineh Mohammadi Chamardani et al.· Cancer Treatment and Researc...· 0 citations
ADH6 and BDH1 were identified as significantly downregulated genes associated with patient survival in CRC and demonstrated promising tissue-based diagnostic discrimination between tumor and normal samples.
F. Kaviani, Samaneh Dalali, Mohammad Mahdevar et al.· Current Genetic Medicine Rep...· 0 citations
Purpose Lung adenocarcinoma (LUAD), the most prevalent lung cancer subtype, has witnessed a dramatic upsurge in frequency over the past 20 years. This study intended to construct a predictive risk model and analyze melatonin (ME)-associated genes in LUAD. Methods Differentially expressed genes (DEGs) were found by usin...
Hong-Xia Guo, Li-Xia Liu, Ying Lu et al.· PLoS ONE· 0 citations
This study aimed to identify prognostic genes associated with papillary thyroid carcinoma (PTC) and explore candidate traditional Chinese medicine (TCM) compounds using integrated bioinformatics and molecular docking. In this observational study, PTC gene expression profiles and clinical data were obtained from The Can...
