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#large language models #generative ai #diffusion models #protein folding #gene editing #small language model

Protein–peptide docking with a rational and accurate diffusion generative model

Huifeng Zhao Odin Zhang Dejun Jiang Zhenxing Wu Hongyan Du Xiaorui Wang Yihao Zhao Yuansheng Huang Jingxuan Ge Tingjun Hou Yu Kang
Aug 2025 · Nature Machine Intelligence · Vol 7, pp. 1308 - 1321 · 21 citations · ⚡ 2 influential · 82 references

TL;DR

RAPiDock is presented, an all-atom diffusion model that predicts peptide–protein binding patterns across 92 amino acid types, enabling high-throughput virtual screening for advancing therapeutic peptide design and serve as a powerful tool for high-throughput virtual screening with structural precision.

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