Open access
Oncologic Outcomes in a Contemporary “PROTEUS-like” Cohort of High-risk Prostate Cancer Treated with Radical Prostatectomy Without Neoadjuvant Hormonal Therapy
Can Aydogdu
Benso John
Clara Seizer
Frederik Kolligs
Iason Papadopoulos
Alexander Buchner
E. Berg
J. Casuscelli
Julie Steinestel
Roman Mayr
Matthias Heck
C. Stief
T. Westhofen
Medicine
Abstract
Take Home Message In men meeting strict PROTEUS high-risk criteria, an upfront radical prostatectomy strategy was associated with substantial biochemical recurrence and metastatic progression. These contemporary outcomes provide a real-world benchmark for contextualizing forthcoming PROTEUS results and informing risk-adapted perioperative strategies.