Engineering inflammation-responsive proteins through nitric oxide-caged amino acids.

ATP-sensing DNA origami nanodevices for targeted modulation of purinergic signaling in inflammatory tissue injury

Dynamic covalent/coordinated nanonetworks with DNase-mimetic and ROS scavenging properties for acute inflammation treatment.

Sterile inflammation driven by cell-free DNA (cfDNA) and reactive oxygen species (ROS) underlies acute inflammatory disorders, yet current therapies fail to specifically target these upstream mediators. We report a dynamic covalent/coordinated nanonetwork (DC2 NNW) that combines drug delivery, DNase-mimetic and ROS-sca...

NIR-Responsive Mitochondrial-Targeted Nanozymes With Built-In Antibacterial Function for Safe Osteoarthritis Therapy.

Osteoarthritis is a prevalent degenerative joint disorder characterized by chronic inflammation and oxidative stress, with current treatments offering limited efficacy in halting disease progression. A central pathogenic driver is the mitochondrial overproduction of reactive oxygen species (ROS), which induces cellular...

Organoselenium compounds as redox modulators of inflammation: Synthetic strategies, mechanistic insights, and therapeutic potential.

Inflammation is a fundamental biological response, whose chronic activation contributes to the development and progression of numerous diseases, including arthritis, cardiovascular and neurodegenerative disorders. As such, the discovery of safe and effective anti-inflammatory drugs remains a central challenge in medici...

Plant-derived extracellular vesicles (PDEVs) in anti-aging research: A review of biomedical characteristics and therapeutic applications.

Aging is a complex, irreversible physiological process characterized by gradual deterioration of tissue structure and function, accompanied by impaired regenerative capacity, dysregulated immune homeostasis, and increased susceptibility to chronic age-related diseases (e.g., neurodegenerative disorders, metabolic syndr...

An Energy-Sustainable and Oxidative-Tolerant Nanofactory of Therapeutic Proteins for Long-Acting Therapy of Inflammatory Bowel Disease.

The ability to continuously generate bioactive therapeutics at the diseased site is an appealing and crucial advantage for the treatment of chronic relapsing diseases such as inflammatory bowel disease (IBD). Current in situ therapeutic factory strategies mainly rely on plasmid drugs, which are usually associated with...