Clinically, reduced SOCS3 expression has been associated with lymph node metastasis, advanced TNM stage, and poorer prognosis, whereas higher SOCS3 levels may correlate with improved outcomes and chemosensitivity, and further translational studies are needed to validate SOCS3 as a biomarker and therapeutic target in CRC.
The transcription factor TWIST1 plays a fundamental role in the regulation of breast cancer initiation, progression, metastasis, and resistance to treatment. As a prominent driver of epithelial-mesenchymal transition (EMT), TWIST1 promotes phenotypic plasticity in cancer cells, enabling enhanced invasion, migration, an...
K. Saleh, R. S., P. Nayak et al.· Mutation research. Reviews i...· 0 citations
Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, largely due to its high metastatic potential and poor prognosis at advanced stages. Epithelial–mesenchymal transition (EMT) is a pivotal biological process that facilitates tumor invasion, dissemination, and therapeutic resista...
M. Saadh, A. K. Bishoyi, R. Roopashree et al.· Biochemistry and Biophysics...· 0 citations
MicroRNAs (miRNAs) are known as potential biomarkers for cancer detection and therapeutic management owing to their epigenetic significance in gene expression and other cellular functions. In this review, evidence has been collected to reach the clinical effect and molecular mechanism of miR-770 in various cancers. MiR...
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer-related mortality worldwide. Despite advances in diagnosis and therapy, the prognosis for advanced HCC remains poor due to late-stage diagnosis, high recurrence rates, therapeutic resistance, and pronounced molecula...
R. Srivastava, Pratibha Singh, D. Lonard· Biomedicines· 0 citations
The JAK/STAT signaling pathway regulates processes such as proliferation, differentiation,
survival, and immune responses. Dysregulation of this pathway is strongly correlated with the
initiation and progression of several malignancies in humans. This pathway consists of Janus Kinases
(JAKs) and Signal Transducers...
Mariyam Rafi, Umme Aiman, S. M. A. Shahid et al.· Current Cancer Therapy Revie...· 0 citations
Tumorigenesis is a complex multistage process, with its primary regulatory mechanisms involving the interplay of genetic alterations, immune dysfunction and metabolic abnormalities. Transcription factors serve a crucial role in gene expression regulation, participating in various tumor behaviors such as proliferation,...
Zhen-Zhe Liu, Zhong Wei, Zhen-Sheng Li et al.· Oncology Letters· 0 citations
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