GM-CSF Programs Alveolar Macrophages to Maintain Pulmonary Lymphocyte Homeostasis

Neutrophils and CSF1 promote the expansion of monocyte-derived alveolar macrophages in progressive pulmonary fibrosis.

Progressive pulmonary fibrosis (PPF) is a fatal lung condition characterized by persistent inflammation and progressive fibrotic remodeling. Monocyte-derived alveolar macrophages (Mo-AMs) are key drivers of fibrogenesis; however, the mechanisms underlying their persistence in fibrotic lungs remain unclear. Using lineag...

REVIEW GM-CSF: from emergency myelopoiesis to central innate immune memory

Macrophage polarization modulates neutrophil extracellular trap dynamics and reciprocal macrophage responses

The interplay between neutrophils and macrophages is central to inflammatory regulation, yet how macrophage polarization governs the homeostasis of neutrophil extracellular traps (NETs) remains poorly understood. Here, we show that the macrophage polarizing environment is a critical determinant of NETs dynamics in huma...

Alternatively polarized neutrophils metabolically restrain macrophage-driven inflammation

Arterial Resident But Not Monocyte-Derived Macrophages Require Endothelial CSF1.

BACKGROUND Tissue-resident macrophages (T-RMøs) accumulate at sites predisposed to atherosclerosis in the healthy aortic intima. T-RMøs require local cues for their maintenance, but the niche signals governing their persistence in arterial tissue remain poorly defined. Here, we identify distinct, spatially compartmenta...

Pathological Th2 cell activation via STAT6 pathway for pulmonary fibrosis.

A CD28-JAK1/STAT6-Th2-monocyte-derived alveolar macrophage pathway is defined as a mechanistic driver of pulmonary fibrosis and nominate CD28 and STAT6 as actionable immunologic targets that could complement existing antifibrotic therapies.