Germline BRCA1 Mutation Deregulates Irradiation–Induced Cell Cycle Checkpoints in Human Mammary Luminal Progenitors

Abhijith Kuttanamkuzhi Bowen Zhang Kelvin Yeung Matthew Waas Pirashaanthy Tharmapalan Soumili Sarkar C. McCloskey Olivia Drummond Guy Hui Fang Shreya Mishra T. Kislinger H. Berman Shane M. Harding R. Khokha

Aug 2026 · bioRxiv · 0 citations · 50 references

Biology

TL;DR

A lineage-resolved monolayer culture system is established that enables propagation of primary human mammary epithelial populations while preserving lineage identity across passages and provides a functional framework for determining critical events in the expansion of genomically altered mammary epithelial cells in the high-risk breast.

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