Aug 2026· Proceedings of the National Academy of Sciences of the United States of America· Vol 123· 0 citations· 86 references
Medicine
TL;DR
The mutant POLD1 enzyme reported here introduces mutations into the viral genome during replication, thereby disrupting the function of essential viral proteins, and is a powerful resistance mechanism that plant geminiviruses cannot escape.
Abstract
Significance The cultivated tomato is the most widely grown vegetable crop worldwide, but its production is severely impacted by geminivirus infections. Therefore, finding robust resistance genes against these infections would be of significant economic benefit. Recently, mutations in DNA POLYMERASE DELTA 1 (POLD1) have been associated with resistance to geminivirus infections. However, the mechanism by which these mutations confer resistance remains unknown. In tomato, mutant POLD1 alleles are located at the Ty-6 resistance locus introgressed from the wild tomato Solanum chilense. The mutant POLD1 enzyme reported here introduces mutations into the viral genome during replication, thereby disrupting the function of essential viral proteins. Currently, the mutant POLD1-mediated inactivation of geminiviruses is a powerful resistance mechanism that plant geminiviruses cannot escape.
The barley yellow mosaic virus disease is one of the most important threats of barley production in Europe and Asia. Transmitted by the soil-borne plasmodiophorid Polymyxa graminis, there are no direct control options against the causal bymoviruses Barley Yellow Mosaic Virus (BaYMV) and Barley Mild Mosaic Virus (BaMMV)...
R. Hoffie, A. Habekuss, D. Perović et al.· bioRxiv· 0 citations
This study demonstrates that expression of tomato leaf curl New Delhi virus CP confers effective resistance against tomato yellow leaf curl China virus (TYLCCNV), another prominent geminivirus, and uncovers a novel mechanism by which a viral effector antagonizes viral CP-mediated host resistance during mixed viral infe...
Shi Wu, Yuzhen Mei, Yuan Chen et al.· Phytopathology Research· 0 citations
Abstract Host–pathogen interactions evolve rapidly within species, providing natural genetic resources for the identification of specific ecological interaction factors. We previously identified RNA viruses that infect the nematodes Caenorhabditis elegans and Caenorhabditis briggsae in a species-specific manner. Wild s...
Aurélien Richaud, Gaotian Zhang, Cigdem Alkan et al.· Molecular biology and evolut...· 0 citations
Most genetic diversity stems from spontaneous mutations, that is, errors in DNA repair or replication. But for dozens of organisms across the tree of life, mutations at specific loci are not spontaneous but developmentally programmed: effectively, some organisms edit their own DNA sequences. This is perhaps most common...
Vincent C. T. Hanlon, Unnati Sonawala, Cian A. A. Raza et al.· bioRxiv· 0 citations
It is shown that non-structural protein-15 (NSP15), a nuclease encoded by coronaviruses, can drive the acquisition of a class of insertion mutations, and numerous examples of potential furin cleavage site acquisition and replacement through insertion mutation during the normal course of coronavirus replication are foun...
C. Bianco, Alex C. Stabell, Manivel Lodha et al.· bioRxiv· 0 citations
The root-knot nematode Meloidogyne incognita is a major constraint to crop production worldwide. The resistance gene Mi-1.2 has been widely deployed in tomato varieties to control this parasite. However, virulent nematode populations, overcoming the Mi-1.2-mediated resistance, have increasingly emerged in fields. Under...
Unknown authors· bioRxiv· 0 citations
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